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Hum. Reprod. Advance Access published online on January 29, 2004
Human Reproduction, doi:10.1093/humrep/deh122
© 2004 by European Society of Human Reproduction and Embryology
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Received June 2, 2003
Revised August 26, 2003

Article

Growth hormone secretion is impaired but not related to insulin sensitivity in non-obese patients with polycystic ovary syndrome

Jacoba A.M. de Boer 1, Cornelis B. Lambalk 2*, Heleen H. Hendriks 2, Claire van Aken 2, Eduard A. van der Veen 3, and Joop Schoemaker 2

1 IJsselmeerziekenhuizen, Department of Obstetrics and Gynaecology, Lelystad, VU Medical Centre, Amsterdam, PO Box 7057, 1007 MB Amsterdam, The Netherlands
2 Division of Reproductive Medicine of the Department of Obstetrics and Gynaecology, VU Medical Centre, Amsterdam, PO Box 7057, 1007 MB Amsterdam, The Netherlands
3 Department of Endocrinology, VU Medical Centre, Amsterdam, PO Box 7057, 1007 MB Amsterdam, The Netherlands

* To whom correspondence should be addressed. E-mail: cb.lambalk{at}vumc.nl.


  Abstract

BACKGROUND: The aim of the study was to elucidate the relationship between growth hormone (GH) secretion and insulin resistance in polycystic ovary syndrome (PCOS) patients. In order to exclude the influence of obesity on these parameters, only non-obese PCOS patients were studied. METHODS: Eleven PCOS patients and 11 controls with a body mass index (BMI) <=25 kg/m2 were studied. PCOS patients were studied on cycle day 14-15, controls on cycle day 5-9. GH secretion was determined by frequent sampling, from 20.00 h to 08.00 h. Insulin sensitivity was determined by a euglycaemic hyperinsulinaemic clamp and was expressed as the M-value. Insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) levels were determined once. RESULTS: Pooled GH levels were significantly lower in PCOS patients than controls, as was GH pulse amplitude. The number of GH pulses was not different between PCOS patients and controls. The M-value was significantly lower in PCOS patients, although a wide overlap between patients and controls was present. IGF-1 and IGFBP-3 levels were not different between the groups. There was no correlation between the M-value and pooled GH or IGF-1 and IGFBP-3 levels. CONCLUSION: Non-obese patients with PCOS have impaired GH secretion and some but not all have impaired insulin sensitivity. These findings indicate that these patients may also be at risk for cardiovascular diseases and/or diabetes mellitus.

Key words: Key words: growth hormone/insulin/PCOS


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