Skip Navigation



Hum. Reprod. Advance Access published online on January 29, 2004
Human Reproduction, doi:10.1093/humrep/deh125
© 2004 by European Society of Human Reproduction and Embryology
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
19/3/645    most recent
deh125v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Jaroudi, K.
Right arrow Articles by Coskun, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jaroudi, K.
Right arrow Articles by Coskun, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Received August 20, 2003
Revised October 6, 2003
Accepted November 4, 2003

Article

Zygote transfer on day 1 versus cleavage stage embryo transfer on day 3: a prospective randomized trial

Kamal Jaroudi 1, Saad Al-Hassan 1, Ulla Sieck 1, Hamad Al-Sufyan 1, Maya Al-Kabra 2, and Serdar Coskun 2*

1 King Faisal Specialist Hospital and Research Center, Department of Obstetrics and Gynecology, P.O.Box 3354, Riyadh, 11211, Saudi Arabia
2 King Faisal Specialist Hospital and Research Center, Department of Pathology and Laboratory Medicine, P.O.Box 3354, Riyadh, 11211, Saudi Arabia

* To whom correspondence should be addressed. E-mail: serdar{at}kfshrc.edu.sa.


  Abstract

BACKGROUND: It has been reported that pronuclear morphology is related to embryo quality and viability, and that zygote stage embryos might establish pregnancies after being transferred to the uterus. The objective of this study was to investigate whether transferring zygotes on day 1 would result in similar pregnancy rates compared to transferring cleavage stage embryos on day 3 in a prospective randomized trial. METHODS: Patients undergoing IVF/ICSI treatments were randomized to either day 1 or day 3 transfers by envelope withdrawal technique. Zygotes were classified as ‘pattern 0’ and ‘non-pattern 0’ according to the size and alignment of pronuclei, the number and distribution of nucleoli. The two best zygotes or embryos were transferred on day 1 or day 3 respectively. The primary outcome measure was pregnancy rate. RESULTS: Pregnancy rates were higher in day 3 group (55/131, 42%) when compared to day 1 (34/123, 28%, P = 0.024). Similarly, implantation rates were higher in day 3 group (P = 0.03). There were more cycles with cryopreservation in the day 1 group (P < 0.001). Embryo quality on day 3 was similar between pattern 0 and non-pattern 0 zygotes. CONCLUSIONS: Day 3 embryo transfers result in better pregnancy and implantation rates compared to day 1 zygote transfers. The present pronuclei scoring cannot reliably select zygotes for transfer on day 1.

Key words: Key words: embryo transfer/pronuclear scoring/zygote


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
A. N. James, S. Hennessy, B. Reggio, K. Wiemer, F. Larsen, and J. Cohen
The limited importance of pronuclear scoring of human zygotes
Hum. Reprod., June 1, 2006; 21(6): 1599 - 1604.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.