Hum. Reprod. Advance Access published online on February 12, 2004
Human Reproduction, doi:10.1093/humrep/deh159
© 2004 by European Society of Human Reproduction and Embryology
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Deartment of Obstetrics and Gynecology, Hokkaido University, Sapporo, Japan
* To whom correspondence should be addressed. E-mail: yhideto{at}med.hokudai.ac.jp.
BACKGROUND: The aim of this study was to assess the natural killer (NK) cell and natural killer T (NKT) cell populations and cytokine expression of T-helper (Th) cells in the endometrium of women who suffered from unexplained repeated miscarriage (RM). METHODS: The percentages of NK cells, NKT cells and CD4+ cells expressing intracellular interferon (IFN)- Key words:
Key words: immunodystrophism/natural killer cell/natural killer T cell/recurrent miscarriage/Th cytokine
Accepted January 5, 2004
Article
No difference in natural killer or natural killer T-cell population, but aberrant T-helper cell population in the endometrium of women with repeated miscarriage
2 Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
3 Department of Public Heath, Hokkaido University Graduate School of Medicine, Hokkaido University, Sapporo, Japan
4 Deartment of Obstetrics and Gynecology, Hokkaido University, Sapporo, Japan; Department of Obstetrics and Gynecology, Graduate School of Medicine, Hokkaido University, Kita-ku N15 W7, Sapporo 060-8638, Japan
Abstract 
, interleukin (IL)-4 and tumour necrosis factor (TNF)-
were measured by flow cytometry in the endometrium of 20 RM women and 17 fertile control women in the mid-luteal phase of the menstrual cycle. RESULTS: No significant differences in CD56+ NK cell or CD3+CD4-CD8-V24+V
11+ NKT cell percentages were found between RM and control women. However, in RM women compared with control women, the percentages of CD3+ cells (mean 40.3 versus 56.5%), CD4+IFN-+ cells (28.4 versus 39.5%) and CD4+TNF-+ cells (32.9 versus 45.8%) were significantly lower. The Th1/Th2 cell balance in RM women did not differ from that of controls. CONCLUSIONS: Immunodystrophism detected as diminution of the Th cell population rather than Th1 predominance, NK cell or NKT cell accentuation in the endometrium might underlie the pathophysiology of unexplained RM. This finding provokes an additional controversy on the Th1/Th2 balance concerning RM aetiology.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Szekeres-Bartho and J. Balasch Progestagen therapy for recurrent miscarriage Hum. Reprod. Update, January 1, 2008; 14(1): 27 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Takeda, H. Yamada, K. Iwabuchi, S. Shimada, M. Naito, N. Sakuragi, H. Minakami, and K. Onoe Administration of high-dose intact immunoglobulin has an anti-resorption effect in a mouse model of reproductive failure Mol. Hum. Reprod., November 1, 2007; 13(11): 807 - 814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sugiura-Ogasawara, K. Nozawa, T. Nakanishi, Y. Hattori, and Y. Ozaki Complement as a predictor of further miscarriage in couples with recurrent miscarriages Hum. Reprod., October 1, 2006; 21(10): 2711 - 2714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yamada, S. Shimada, M. Morikawa, K. Iwabuchi, R. Kishi, K. Onoe, and H. Minakami Divergence of natural killer cell receptor and related molecule in the decidua from sporadic miscarriage with normal chromosome karyotype Mol. Hum. Reprod., June 1, 2005; 11(6): 451 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Dosiou and L. C. Giudice Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunologic Perspectives Endocr. Rev., February 1, 2005; 26(1): 44 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Moffett, L. Regan, and P. Braude Natural killer cells, miscarriage, and infertility BMJ, November 27, 2004; 329(7477): 1283 - 1285. [Full Text] [PDF]
|
|