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Hum. Reprod. Advance Access published online on February 27, 2004
Human Reproduction, doi:10.1093/humrep/deh161
© 2004 by European Society of Human Reproduction and Embryology
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Received August 4, 2003
Revised November 10, 2003
Accepted January 8, 2004

Article

Transient hypogonadotrophic hypogonadism in males with acute toxoplasmosis: suppressive effect of interleukin-1{beta} on the secretion of GnRH

Cagatay Oktenli 1*, Levent Doganci 2, Taner Ozgurtas 3, R.Engin Araz 2, Mehmet Tanyuksel 2, Ugur Musabak 4, S.Yavuz Sanisoglu 5, Zeki Yesilova 1, M.Kemal Erbil 3, and Ali Inal 4

1 Department of Internal Medicine, Gulhane Military Medical Academy, TR-06018 Etlik-Ankara, Turkey
2 Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy, TR-06018 Etlik-Ankara, Turkey
3 Department of Biochemistry, Gulhane Military Medical Academy, TR-06018 Etlik-Ankara, Turkey
4 Department of Immunology, Gulhane Military Medical Academy, TR-06018 Etlik-Ankara, Turkey
5 Department of Biostatistics, Gulhane Military Medical Academy, TR-06018 Etlik-Ankara, Turkey

* To whom correspondence should be addressed. E-mail: coktenli{at}ttnet.net.tr.


  Abstract

BACKGROUND: In September 2002, an outbreak of toxoplasmosis was noted in a male boarding high school on the Aegean coast of Turkey. We have focused our efforts to investigate the sex hormones in this population. METHODS: Blood samples were collected from 40 male patients, 17-18 years old, who also had positive titres of antibody to Toxoplasma gondii. Serum FSH, LH, free testosterone (FT), total testosterone (TT), interferon-{gamma} (IFN-{gamma}), interleukin-1{beta} (IL-1{beta}) and macrophage-inflammatory protein-1{alpha} (MIP-1{alpha}) concentrations were measured in all patients and 20 control subjects. Initially, the patients were divided on the basis of the levels of sex hormones into the following groups: patients who had normal sex hormone levels (n = 31) as group A and patients with low sex hormone levels (n = 9) as group B. RESULTS: IL-1{beta} levels were found to be higher in group B patients than group A. The levels of IL-1{beta} correlated significantly in a negative manner with FSH, LH, FT and TT in all patients with acute toxoplasmosis (n = 40). CONCLUSIONS: Acute toxoplasma infection may cause temporary hypogonadotrophic gonadal insufficiency regardless of the course of the disease.

Key words: Key words: hypogonadotrophic hypogonadism/interferon-{gamma}/interleukin-1{beta}/macrophage-inflammatory protein-1{alpha}/toxoplasmosis


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