Hum. Reprod. Advance Access published online on March 11, 2004
Human Reproduction, doi:10.1093/humrep/deh163
© 2004 by European Society of Human Reproduction and Embryology
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1 Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China; Department of Obstetrics and Gynaecology, The University of Hong Kong, 6/F, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong
* To whom correspondence should be addressed. E-mail: nghye{at}hkucc.hku.hk.
BACKGROUND: Impaired implantation in assisted reproduction cycles with high serum estradiol (E2) concentrations may be attributed to abnormal endometrial development. This study compared concentrations of endometrial proteins in uterine flushings of infertile patients between natural and stimulated cycles. METHODS: Patients received a standard regimen of ovarian stimulation. Seven days after the LH surge in natural cycles or the hCG injection in stimulated cycles, uterine flushings were performed by slowly injecting and aspirating normal saline through a paediatric Foley catheter. Natural cycles were considered as group A whereas stimulated cycles with serum E2 <20 000 pmol/l and serum E2 >20 000 pmol/l were classified as groups B and C respectively. PP 14 and CA-125 in uterine flushings were measured and expressed per total protein content. RESULTS: Concentrations of the total protein, PP 14 and CA-125 in the uterine flushings were similar among the three groups. PP 14 per total protein in the uterine flushings was significantly correlated with serum E2 on the day of hCG (r = 0.459; P = 0.009) in natural cycles only but not in stimulated cycles. CONCLUSION: There was no significant difference between natural and stimulated cycles in concentrations of PP 14 and CA-125 in uterine flushings performed in the mid-luteal phase. Key words:
Key words: CA-125/excessive responders/PP 14/uterine flushing
Accepted January 8, 2004
Article
Concentrations of endometrial protein PP 14 and CA-125 in uterine flushings performed in natural and stimulated cycles
2 Division of Biomedical Sciences, Sheffield Hallam University, City Campus, Sheffield, UK
3 Centre for Reproductive Medicine and Fertility, The Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK
4 Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China
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