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Hum. Reprod. Advance Access published online on May 27, 2004
Human Reproduction, doi:10.1093/humrep/deh241
© 2004 by European Society of Human Reproduction and Embryology
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Received March 15, 2003
Accepted March 10, 2004

Case report

In vitro maturation and fertilization of oocytes from an intact ovary of a surgically treated patient with endometrial carcinoma: Case report

A. Revel 1*, A. Safran 1, A. Benshushan 1, A. Shushan 1, N. Laufer 1, A. Simon 1

1 In vitro Fertilization Unit, Department of Obstetrics and Gynecology, Hadassah University Hospital, Ein Kerem, PO Box 12000, Jerusalem 91120, Israel

* To whom correspondence should be addressed. E-mail: revel{at}md.huji.ac.il.


  Abstract

Polycystic ovary syndrome (PCOS) with prolonged anovulation had resulted in endometrial carcinoma in a 43-year-old woman. Since she and her husband did not share common biological children, they requested fertility preservation. Due to the woman’s age, high dose progesterone and postponing surgery were both considered inappropriate. We therefore proposed oocyte retrieval from the ovaries removed by staging laparotomy followed by in vitro maturation and ICSI. Surrogacy could then enable a future pregnancy. Fourteen of 17 (82%) retrieved oocytes matured in vitro. Following ICSI, eight embryos (two at the pronuclear stage and six cleaved) were cryopreserved. To the best of our knowledge, this is the first report of oocyte aspiration, maturation and fertilization from an ovary removed by laparotomy.

Key words: embryo cryopreservation/endometrial carcinoma/fertility preservation/in vitro maturation/polycystic ovary syndrome


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