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Hum. Reprod. Advance Access published online on May 20, 2004
Human Reproduction, doi:10.1093/humrep/deh254
© 2004 by European Society of Human Reproduction and Embryology
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Received July 14, 2003
Accepted March 12, 2004

Article

Use of artificial dermis and recombinant basic fibroblast growth factor for creating a neovagina in a patient with Mayer-Rokitansky-Küster-Hauser syndrome

Soichi Noguchi 1*, Mikiya Nakatsuka 1, Yuka Sugiyama 1, Chebib Chekir 1, Yasuhiko Kamada 1, Yuji Hiramatsu 1

1 Department of Obstetrics and Gynecology, Okayama University Medical School, 2-5-1 Shikata, Okayama-city, Okayama 700-8558, Japan

* To whom correspondence should be addressed. E-mail: soichi{at}d2.dion.ne.jp.


  Abstract

Vaginal agenesis is an uncommon, but not rare, condition. Although there are many methods for creating a neovagina, the optimal treatment is unknown. An 18-year-old woman with Mayer-Rokitansky-Küster-Hauser syndrome received vaginoplasty with a modified Wharton procedure using an artificial dermis (atelocollagen sponge). From 10 days after the operation, the patient was administered human recombinant basic fibroblast growth factor (bFGF) spray to accelerate epithelialization on the neovagina. At 50 days after the operation, we confirmed histological squamous epithelialization of the vaginal epithelium. At 12 months after the operation, the neovagina was at least 3.5 cm in width and ~8 cm in length. In this case, use of artificial dermis and recombinant bFGF to create a neovagina was an easy, less invasive and useful method.

Key words: artificial dermis/bFGF/vaginoplasty/Mayer-Rokitansky-Küster-Hauser syndrome


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