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Hum. Reprod. Advance Access published online on June 10, 2004
Human Reproduction, doi:10.1093/humrep/deh345
© 2004 by European Society of Human Reproduction and Embryology
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Received February 10, 2004
Accepted April 30, 2004

Case report

Evidence of parthenogenetic origin of ovarian teratoma: Case report

Flávio Garcia Oliveira 1*, Dmitri Dozortsev 1, Michael Peter Diamond 2, Adriana Fracasso 1, Soraya Abdelmassih 1, Vicente Abdelmassih 1, Sergio Pereira Gonçalves 1, Roger Abdelmassih 1, Zolt Peter Nagy 3

1 Clínica e Centro de Pesquisa em Reprodução Humana ‘Roger Abdelmassih’, São Paulo, Brazil
2 Hutzel Hospital, Wayne State University, Detroit, MI, USA
3 Reproductive Biology Associates, 1150 Lake Hearn Dr Suite 600, Atlanta, GA 30342, USA

* To whom correspondence should be addressed. E-mail: flaviogo2{at}uol.com.br.


  Abstract

This case report represents one of the few documented cases of parthenote embryo retrieval from an IVF patient with a history of ovarian teratomas. A 29-year-old woman presented at our centre with a history of primary infertility for 6 years due to male factor. She had undergone left oophorectomy 4 years before due to an ovarian teratoma. An ultrasound scan performed during basal evaluation revealed two complex images in the right ovary suggesting teratomas, measuring 2.5 x 2.4 and 1.7 x 1.3 cm. A significant extent of sonographically normal ovarian parenchyma was present, and the patient underwent the long leuprolide acetate protocol of ovarian stimulation with recombinant FSH for an IVF-ICSI cycle. She had 13 metaphase II (MII), four metaphase I (MI), two germinal vesicle (GV) oocytes and one 4-cell embryo retrieved. Eight out of nine injected oocytes were fertilized normally while one was unfertilized. Embryo transfer was carried out 72 h after retrieval. The 4-cell (parthenote) embryo recovered at oocyte retrieval continued to cleave in culture, developing into a 7-cell embryo by the next day. The embryo was morphologically normal, presenting an evident nucleus in each blastomere. Fluorescent in situ hybridization (FISH) returned two signals for the X chromosome in each blastomere that was analysed. Of the eight normally fertilized embryos, three were transferred, resulting in a normal singleton pregnancy and the birth of a healthy baby.

Key words: embryo, FISH/IVF-ICSI, ovarian teratoma, parthenogenetic oocyte activation


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