Hum. Reprod. Advance Access published online on June 10, 2004
Human Reproduction, doi:10.1093/humrep/deh369
© 2004 by European Society of Human Reproduction and Embryology
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1 Centre for Reproductive Medicine, Jean Verdier Hospital, A.P.-H.P., 93143 Bondy - University Paris XIII, France
* To whom correspondence should be addressed. E-mail: isabelle.cedrin-durnerin{at}jvr.ap-hop-paris.fr.
BACKGROUND: When administered in the late follicular phase to prevent an LH surge, GnRH antagonists induce a sharp decrease in serum LH levels that may be detrimental for assisted reproductive technology cycle outcome. Therefore, a prospective study was designed to assess the effects of recombinant human (r)LH supplementation during GnRH antagonist (cetrorelix) administration. METHODS: The protocol consisted of cycle programming with oral contraceptive pill, ovarian stimulation with rFSH and flexible administration of a single dose of cetrorelix (3 mg). A total of 218 patients from three IVF centres were randomized (by sealed envelops or according to woman's birth date) to receive (n=114) or not (n=104) a daily injection of rLH 75 IU from GnRH antagonist initiation to hCG injection. RESULTS: The only significant difference was a higher serum peak E2 level in patients treated with rLH (1476±787 versus 1012±659 pg/ml, P<0.001) whereas the numbers of oocytes and embryos as well as the delivery rate (25.2 versus 24%) and the implantation rate per embryo (19.1 versus 17.4%) were similar in both groups. CONCLUSIONS: These results show that in an unselected group of patients, there is no evident benefit to supplement GnRH antagonist-treated cycles with rLH. Key words:
assisted reproductive technology, controlled ovarian stimulation, GnRH antagonist, rLH
Accepted May 19, 2004
Article
Recombinant human LH supplementation during GnRH antagonist administration in IVF/ICSI cycles: a prospective randomized study
2 ART Centre, Clinique du Blanc Mesnil, 93150 Le Blanc Mesnil, France
3 IVF Centre, Aquitaine Santé Médecine de la Reproduction, 33 523 Bruges Cedex, France
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