Skip Navigation



Hum. Reprod. Advance Access published online on July 29, 2004
Human Reproduction, doi:10.1093/humrep/deh375
© 2004 by European Society of Human Reproduction and Embryology
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
19/9/1993    most recent
deh375v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hwang, J.-L.
Right arrow Articles by Tzeng, C.-R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hwang, J.-L.
Right arrow Articles by Tzeng, C.-R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Received June 10, 2003
Accepted May 10, 2004

Article

Ovarian stimulation by concomitant administration of cetrorelix acetate and HMG following Diane-35 pre-treatment for patients with polycystic ovary syndrome: a prospective randomized study

Jiann-Loung Hwang 1*, Kok-Min Seow 2, Yu-Hung Lin 3, Lee-Wen Huang 4, Bih-Chwen Hsieh 3, Yieh-Loong Tsai 4, Gong-Jhe Wu 4, Shih-Chia Huang 4, Chin-Yu Chen 4, Pei-Hsin Chen 4, Chii-Ruey Tzeng 5

1 Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, Department of Obstetrics and Gynecology, Taipei Medical University, Taipei, Taiwan
2 Department of Obstetrics and Gynecology, E-Da Hospital/I-Shou University, Kaohsiung County, Taiwan
3 Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, College of Medicine, Fu Jen Catholic University, Sinchuang City, Taipei County, Taiwan
4 Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
5 Department of Obstetrics and Gynecology, Taipei Medical University, Taipei, Taiwan

* To whom correspondence should be addressed. E-mail: m001015{at}ms.skh.org.tw.


  Abstract

BACKGROUND: Patients with polycystic ovary syndrome (PCOS) may need a longer period of pituitary downregulation to suppress the elevated serum LH and androgen levels effectively during IVF treatment using the GnRH agonist long protocol. We proposed a stimulation protocol incorporating Diane-35 and GnRH antagonist (Diane/cetrorelix protocol) and compared it with the GnRH agonist long protocol for PCOS patients. METHODS: Part I of the study was an observational pilot study to evaluate the hormonal change as a result of the Diane/cetrorelix protocol (n=26). Part II of the study was a prospective randomized study comparing the Diane/cetrorelix protocol (n=25) and the GnRH agonist long protocol (n=24). In the Diane/cetrorelix protocol, patients were pre-treated with three cycles of Diane-35, followed by 0.25 mg of cetrorelix on cycle day 3. From day 4, cetrorelix and gonadotrophin were administered concomitantly until the day of HCG injection. RESULTS: Serum LH, estradiol and testosterone levels were suppressed comparably in both protocols at the start of gonadotrophin administration. Serum LH was suppressed at constant levels without a premature LH surge in the Diane/cetrorelix protocol. The clinical results for both protocols were comparable, with significantly fewer days of injection, lower amounts of gonadotrophin used and lower estradiol levels on the day of HCG injection following the Diane/cetrorelix protocol. Furthermore, there was no significant difference in clinical pregnancy outcome between the two stimulation protocols. CONCLUSIONS: The Diane/cetrorelix protocol has a similar pregnancy outcome to the GnRH agonist long protocol for women with PCOS undergoing IVF treatment.

Keywords: cetrorelix acetate; Diane-35; HMG; GnRH antagonist; PCOS.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
J.A. Huirne, R. Homburg, and C.B. Lambalk
Are GnRH antagonists comparable to agonists for use in IVF?
Hum. Reprod., November 1, 2007; 22(11): 2805 - 2813.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. G. Lainas, G. K. Petsas, I. Z. Zorzovilis, G. S. Iliadis, G. T. Lainas, H. E. Cazlaris, and E. M. Kolibianakis
Initiation of GnRH antagonist on Day 1 of stimulation as compared to the long agonist protocol in PCOS patients. A randomized controlled trial: effect on hormonal levels and follicular development
Hum. Reprod., June 1, 2007; 22(6): 1540 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K.-M. Seow, C.-C. Juan, L.-T. Ho, Y.-P. Hsu, Y.-H. Lin, L.-W. Huang, and J.-L. Hwang
Adipocyte resistin mRNA levels are down-regulated by laparoscopic ovarian electrocautery in both obese and lean women with polycystic ovary syndrome
Hum. Reprod., April 1, 2007; 22(4): 1100 - 1106.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
E.M. Kolibianakis, J. Collins, B.C. Tarlatzis, P. Devroey, K. Diedrich, and G. Griesinger
Among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis
Hum. Reprod. Update, November 1, 2006; 12(6): 651 - 671.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
B.C. Tarlatzis, B.C. Fauser, E.M. Kolibianakis, K. Diedrich, P. Devroey, and , On Behalf of the Brussels GnRH Antagonist Consen
GnRH antagonists in ovarian stimulation for IVF
Hum. Reprod. Update, July 1, 2006; 12(4): 333 - 340.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J.A. Huirne, J.N. Hugues, C. Pirard, F. Fischl, J.C. Sage, J.L. Pouly, A. Obruca, D.M. Braat, A.C.D. van Loenen, and C.B. Lambalk
Cetrorelix in an oral contraceptive-pretreated stimulation cycle compared with buserelin in IVF/ICSI patients treated with r-hFSH: a randomized, multicentre, phase IIIb study
Hum. Reprod., June 1, 2006; 21(6): 1408 - 1415.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.