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Hum. Reprod. Advance Access published online on July 8, 2004
Human Reproduction, doi:10.1093/humrep/deh412
© 2004 by European Society of Human Reproduction and Embryology
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Received February 24, 2004
Accepted June 7, 2004

Article

Concentration of osteoprotegerin (OPG) in peritoneal fluid is increased in women with endometriosis

Miyuki Harada 1, Yutaka Osuga 1*, Tetsuya Hirata 1, Yasushi Hirota 1, Kaori Koga 1, Osamu Yoshino 1, Chieko Morimoto 1, Toshihiro Fujiwara 1, Mikio Momoeda 1, Tetsu Yano 1, Osamu Tsutsumi 1, Yuji Taketani 1

1 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

* To whom correspondence should be addressed. E-mail: yutakaos-tky{at}umin.ac.jp.


  Abstract

BACKGROUND: Failure of apoptosis of refluxed endometrial cells within the peritoneal cavity is a possible etiologic factor for development of endometriosis. Osteoprotegerin (OPG) is a survival factor that exerts its effect by binding to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), thus preventing TRAIL from binding to the apoptosis receptors DR4 and DR5. In the present study, we addressed the possibility that the TRAIL/OPG system is involved in the pathogenesis of endometriosis. METHODS: Concentrations of OPG and TRAIL in the peritoneal fluid (PF) of women with or without endometriosis were measured using specific enzyme-linked immunoabsorbent assay. The expression of DR4 and DR5 in the endometriotic tissue was examined by reverse transcription-polymerase chain reaction. RESULTS: OPG concentrations in PF of women with endometriosis were significantly higher than those of women without endometriosis (P=0.006). With respect to the stages of the disease, the concentrations of OPG in women with stage III/IV endometriosis were significantly higher than in those without endometriosis and those with stage I/II endometriosis. On the other hand, the ratios of TRAIL/OPG concentrations were significantly lower in stage III/IV endometriosis compared to those in non-endometriosis and stage I/II endometriosis. DR5 mRNA expression was clearly detected in all the endometriotic tissues studied. CONCLUSIONS: These findings suggest that the TRAIL/OPG system is involved in the pathophysiology of endometriosis, possibly affecting the apoptosis of endometriotic cells.


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