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Hum. Reprod. Advance Access published online on August 27, 2004
Human Reproduction, doi:10.1093/humrep/deh483
© 2004 by European Society of Human Reproduction and Embryology
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Received May 25, 2004
Accepted July 26, 2004

Article

Maternal KIR repertoire is not associated with recurrent spontaneous abortion

C.S. Witt 1*, J. Goodridge 2, M.G. Gerbase-DeLima 3, S. Daher 4, F.T. Christiansen 5

1 Department of Clinical Immunology, Royal Perth Hospital, Perth, West Australia, 6000; West Australian Institute for Medical Research, Royal Perth Hospital, Perth West Australia, 6000
2 School of Surgery and Pathology, University of West Australia, Perth, West Australia, 6912
3 Immunogenetics Division, Pediatrics Department, Universidade Federal de São Paulo, Brazil
4 Obstetrics Department, Universidade Federal de Sao Paulo, Brazil
5 Department of Clinical Immunology, Royal Perth Hospital, Perth, West Australia, 6000; School of Surgery and Pathology, University of West Australia, Perth, West Australia, 6912; West Australian Institute for Medical Research, Royal Perth Hospital, Perth West Australia, 6000

* To whom correspondence should be addressed. E-mail: Campbell.Witt{at}health.wa.gov.au.


  Abstract

BACKGROUND: In view of evidence suggesting an immunological cause of recurrent spontaneous abortions (RSA) and the large number of maternal natural killer (NK) cells present in the pregnant uterus, we investigated the genetic polymorphism of the killer cell immunoglobulin-like receptors (KIR) in women with RSA. METHODS: KIR gene repertoire and KIR2DL4 (a receptor for HLA-G) genotyping were determined by SSP and SSCP respectively, in women experiencing RSA and controls. RESULTS: The KIR repertoire did not differ between RSA patients and controls in terms of: (i) the number of inhibitory receptors; (ii) the number of activating receptors; (iii) the ratio of inhibitory to activating receptors. KIR2DL4, a receptor for HLA-G, has different transmembrane alleles, which produce functionally different phenotypes. The frequency of KIR2DL4 transmembrane genotypes differed significantly between RSA patients and controls (P=0.03). However, although homozygosity for a membrane-bound receptor was more frequent in patients (25%) than controls (10%), other genotypes that would produce the same phenotype were not more frequent in patients than controls. CONCLUSIONS: The data provide little evidence that KIR polymorphism plays a role in predisposition to RSA.

Keywords: killer cell immunoglobulin-like receptors; NK cell; recurrent spontaneous abortion.
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