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Hum. Reprod. Advance Access published online on November 11, 2004

Human Reproduction, doi:10.1093/humrep/deh579
© 2004 by European Society of Human Reproduction and Embryology
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Received September 6, 2004
Accepted September 29, 2004

Article

ESHRE PGD Consortium ‘Best practice guidelines for clinical preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS)’

A.R. Thornhill 1*, C.E. deDie-Smulders 2, J.P. Geraedts 2, J.C. Harper 3, G.L. Harton 4, S.A. Lavery 5, C. Moutou 6, M.D. Robinson 7, A.G. Schmutzler 8, P.N. Scriven 9, K.D. Sermon 10, and L. Wilton 11

1 Section of Reproductive Endocrinology and Infertility, Mayo Clinic, College of Medicine Rochester, MN, USA
2 Department of Clinical Genetics, University Hospital Maastricht, Maastricht, The Netherlands
3 Department of Obstetrics and Gynaecology, University College, London, UK
4 Genetics and IVF Institute, Fairfax, VA, USA
5 Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, UK
6 Service de Biologie de la Reproduction, SIHCUS-CMCO, 19 Rue Louis Pasteur, BP120, 67303 Schiltigheim, France
7 The Leeds PGD Centre, Assisted Conception Unit, Leeds General Infirmary, Leeds, UK
8 Section of Reproductive Medicine, University of Kiel, Germany
9 Department of Cytogenetics, and Centre for Preimplantation Genetic Diagnosis, Guy's and St. Thomas' NHS Trust, Guy's Hospital, London, UK
10 Centre for Medical Genetics, Dutch-speaking Brussels Free University, Brussels, Belgium
11 Melbourne IVF, 320 Victoria Parade, 3002 East Melbourne VIC, Australia


   Abstract

Among the many educational materials produced by the European Society of Human Reproduction and Embryology (ESHRE) are guidelines. ESHRE guidelines may be developed for many reasons but their intent is always to promote best quality practices in reproductive medicine. In an era in which preimplantation genetic diagnosis (PGD) has become a reality, we must strive to maintain its efficacy and credibility by offering the safest and most effective treatment available. The dominant motivators for the development of current comprehensive guidelines for best PGD practice were (i) the absence of guidelines and/or regulation for PGD in many countries and (ii) the observation that no consensus exists on many of the clinical and technical aspects of PGD. As a consequence, the ESHRE PGD Consortium undertook to draw up guidelines aimed at giving information, support and guidance to potential, fledgling and established PGD centres. The success of a PGD treatment cycle is the result of great attention to detail. We have strived to provide a similar level of detail in this document and hope that it will assist staff in achieving the best clinical outcome for their patients.

Keywords: ESHRE guidelines; preimplantation genetic diagnosis; preimplantation genetic screening.
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