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Hum. Reprod. Advance Access published online on November 4, 2004
Human Reproduction, doi:10.1093/humrep/deh603
© 2004 by European Society of Human Reproduction and Embryology
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Received May 14, 2004
Revised August 9, 2004
Accepted October 15, 2004

Article

In vitro oocyte maturation for the treatment of infertility associated with polycystic ovarian syndrome: the French experience

A. Le Du 1*, I.J. Kadoch 2, N. Bourcigaux 3, S. Doumerc 3, M-C. Bourrier 3, N. Chevalier 3, R. Fanchin 3, R-C. Chian 4, G. Tachdjian 1, R. Frydman 3, and N. Frydman 1

1 Service de Biologie et Génétique de la Reproduction, Hôpital Antoine Béclère, Clamart, France
2 Service de Gynécologie, Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, France; Present address: Department of Obstetrics and Gynecology, Saint-Luc Hospital (CHUM), Montréal, Québec, Canada
3 Service de Gynécologie, Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, France
4 Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital, Montréal, Québec, Canada

* To whom correspondence should be addressed.
A. Le Du, E-mail: anne.ledu{at}abc.ap-hop-paris.fr


  Abstract

BACKGROUND: In vitro oocyte maturation (IVM) permits the use of immature oocytes in IVF. IVM does not require ovarian stimulation and so can be offered to patients at risk of ovarian hyperstimulation syndrome. METHODS: For this indication, we carried out 45 cycles of IVM in 33 women with polycystic ovarian syndrome (PCOS). RESULTS: A total of 509 cumulus-oocyte complexes was obtained; 276 (54.2%) oocytes matured in 24 h and 45 (8.8%) in 48 h. The normal fertilization (2PN) rate of oocytes matured in 24 and 48 h was 69.5 and 73.3% respectively. Among the 214 embryos obtained, 103 were transferred and 30 were frozen. Forty transfers were performed (2.5 embryos/transfer). Eleven women had a positive {beta}-hCG test (26.2% of pregnancies/puncture, 27.5% of pregnancies/transfer) and nine women had a clinical pregnancy (20.0% of pregnancies/puncture, 22.5% of pregnancies/transfer). Five babies have been born and one pregnancy is ongoing. Results of the clinical examination carried out at birth were normal. CONCLUSIONS: Our results show that IVM may be offered as an alternative to conventional IVF and to ovarian drilling in women with PCOS. The role of IVM in the therapeutic armamentarium for this condition should be further clarified.

Keywords: in vitro maturation; oocyte; ovarian hyperstimulation syndrome; polycystic ovary syndrome.
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