Skip Navigation



Hum. Reprod. Advance Access published online on November 18, 2004
Human Reproduction, doi:10.1093/humrep/deh607
© 2004 by European Society of Human Reproduction and Embryology
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/2/543    most recent
deh607v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Foster, C. M.
Right arrow Articles by Padmanabhan, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Foster, C. M.
Right arrow Articles by Padmanabhan, V.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Received April 22, 2004
Revised August 16, 2004
Accepted October 15, 2004

Article

Diurnal changes in FSH-regulatory peptides and their relationship to gonadotrophins in pubertal girls

Carol M. Foster 1*, Pamela R. Olton 1, and Vasantha Padmanabhan 1

1 Department of Pediatrics/Endocrinology and Reproductive Sciences Program, University of Michigan, Ann Arbor, MI 48109-0718, USA

* To whom correspondence should be addressed.
Carol M. Foster, E-mail: Cmfoster{at}umich.edu


  Abstract

BACKGROUND: FSH-regulatory peptides participate with GnRH and sex steroids to regulate serum FSH concentrations. We hypothesized that day/night variations in FSH serum concentrations would be associated with diurnal variation in FSH-regulatory peptides. METHODS: Blood was obtained every 15 min for 24 h beginning at 08:00 h in eight girls [seven with variations in growth or puberty and one with idiopathic hypogonadotrophic hypogonadism (IHH)] and for 12 h beginning at 20:00 h in 12 additional girls with variant puberty, eight with gonadal dysgenesis or ovarian failure (GD/OF) and one with IHH. Samples across 3 h blocks were pooled for determination of LH, FSH, activin-A, inhibin-B and follistatin 288. RESULTS: LH and FSH concentrations increased from 23:00 to 08:00 h with respect to daytime concentrations in pubertal girls (P<0.005) but only LH increased (P=0.002) in girls with GD/OF. In pubertal girls, inhibin-B declined during the day (P=0.019), reaching a nadir between 17:00 and 22:45 h just prior to the night-time increase in FSH. Follistatin concentrations exhibited diurnal variation (P=0.028), with the greatest concentrations occurring between 05:00 and 11:00 h. Activin-A concentrations declined coincident with the night-time increase in FSH in pubertal girls (P<0.0001) but not in girls with GD/OF. CONCLUSIONS: The directionality of changes in FSH-regulatory proteins supports the notion that FSH-regulatory peptides may contribute to the night-time augmentation of circulating FSH during puberty in girls.

Keywords: activin; follistatin; FSH; inhibin; puberty.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Integr. Comp. Biol.Home page
W. P. Williams III, E. M. Gibson, C. Wang, S. Tjho, N. Khattar, G. E. Bentley, K. Tsutsui, and L. J. Kriegsfeld
Proximate mechanisms driving circadian control of neuroendocrine function: Lessons from the young and old
Integr. Comp. Biol., November 1, 2009; 49(5): 519 - 537.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P. Florio, F.M. Reis, P.B. Torres, F. Calonaci, M.S. Abrao, L.L. Nascimento, M. Franchini, L. Cianferoni, and F. Petraglia
High serum follistatin levels in women with ovarian endometriosis
Hum. Reprod., October 1, 2009; 24(10): 2600 - 2606.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Fahrenkrug, B. Georg, J. Hannibal, P. Hindersson, and S. Gras
Diurnal Rhythmicity of the Clock Genes Per1 and Per2 in the Rat Ovary
Endocrinology, August 1, 2006; 147(8): 3769 - 3776.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.