Skip Navigation



Hum. Reprod. Advance Access published online on November 26, 2004
Human Reproduction, doi:10.1093/humrep/deh626
© 2004 by European Society of Human Reproduction and Embryology
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/2/437    most recent
deh626v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Clementini, E.
Right arrow Articles by Tiboni, G.M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clementini, E.
Right arrow Articles by Tiboni, G.M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Received March 10, 2004
Revised August 24, 2004
Accepted October 29, 2004

Article

Prevalence of chromosomal abnormalities in 2078 infertile couples referred for assisted reproductive techniques

E. Clementini 1, C. Palka 2, I. Iezzi 2, L. Stuppia 3, P. Guanciali-Franchi 2, and G.M. Tiboni 1*

1 Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina e Scienze dell'Invecchiamento,, Chieti, Italy
2 Sezione di Genetica, Dipartimento di Scienze Biomediche, Facoltà di Medicina e Chirurgia, Università ‘G.d'Annunzio’, Facolta di Medicina e Chirurgia, Università ‘G.d’ Annunzio', Ospedale ‘SS. Annunziata, Via dei Vestini, 66013-Chieti, Italy and
3 Sezione di Genetica, Dipartimento di Scienze Biomediche, Facoltà di Medicina e Chirurgia, Università ‘G.d'Annunzio’, Facolta di Medicina e Chirurgia, Università ‘G.d’ Annunzio', Ospedale ‘SS. Annunziata, Via dei Vestini, 66013-Chieti, Italy and I.T.O.I.-CNR, Bologna, Italy

* To whom correspondence should be addressed.
G.M. Tiboni, E-mail: tiboni{at}unich.it


  Abstract

BACKGROUND: This study analyses the prevalence of karyotype changes and Yq11 microdeletions among couples referred for assisted reproduction techniques. METHODS: Prior to receiving either IVF or ICSI treatment, each partner of 2078 infertile couples was screened for karyotype changes by GTG-banding technique on peripheral lymphocytes. No subject presented with obvious phenotype of chromosomal rearrangement. All the oligo/azoospermic men with normal karyotype were further investigated by PCR for Yq11 microdeletions. RESULTS: Eighty-two out of 2078 couples (3.95%) had one partner carrying a chromosomal change, and 10 out of 202 (4.95%) men showed Yq11 microdeletions. The chromosomal rearrangements were 44 (2.1%) translocations, 23 (1.1%) gonosomal mosaics, six (0.3%) 47,XXY, five (0.24%) marker chromosomes, three (0.14%) inversions and one (0.05%) duplication. Frequency of anomalies in men and women were similar: 42 and 40 cases respectively. CONCLUSIONS: Partners of infertile couples requiring IVF or ICSI treatment appear to be affected by higher frequency of chromosomal rearrangements than the general population. Categories with greater risk were represented by men with sperm cell count <20 x 106 sperm/ml, and women with history of pregnancy loss.

Keywords: assisted reproduction techniques; chromosomal aberration; infertility; Yq11 microdeletion.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
C. Gutierrez-Mateo, J. Benet, H. Starke, M. Oliver-Bonet, S. Munne, T. Liehr, and J. Navarro
Karyotyping of human oocytes by cenM-FISH, a new 24-colour centromere-specific technique
Hum. Reprod., December 1, 2005; 20(12): 3395 - 3401.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E.G. Papanikolaou, V. Vernaeve, E. Kolibianakis, E.V. Assche, M. Bonduelle, I. Liebaers, A. Van Steirteghem, and P. Devroey
Is chromosome analysis mandatory in the initial investigation of normovulatory women seeking infertility treatment?
Hum. Reprod., October 1, 2005; 20(10): 2899 - 2903.
[Abstract] [Full Text] [PDF]

Home page
 JWatch Women's HealthHome page
Chromosomal Abnormalities Among Infertile Couples
Journal Watch Women's Health, April 19, 2005; 2005(419): 9 - 9.
[Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.