Skip Navigation



Hum. Reprod. Advance Access published online on February 2, 2005
Human Reproduction, doi:10.1093/humrep/deh654
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/3/683    most recent
deh654v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Oliver-Bonet, M.
Right arrow Articles by Martin, R.H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oliver-Bonet, M.
Right arrow Articles by Martin, R.H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction © European Society of Human Reproduction and Embryology 2005; all rights reserved
Received October 12, 2004
Revised November 9, 2004
Accepted November 16, 2004

Article

Meiotic studies in two human reciprocal translocations and their association with spermatogenic failure

M. Oliver-Bonet 1, J. Benet 2, F. Sun 1, J. Navarro 2, C. Abad 3, T. Liehr 4, H. Starke 4, C. Greene 5, E. Ko 6, and R.H. Martin 1*

1 University of Calgary, Calgary T2N 4N1, Canada, Department of Genetics, Alberta Children's Hospital, Calgary T2T 5C7, Canada
2 Unitat de Biologia, Facultat de Medicina, Departament de Biologia Cellular, Fisiologia i d'Immunologia, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain
3 Corporació Sanitària Parc Taulí, 08208, Sabadell, Spain
4 Institute of Human Genetics and Anthropology, D-07740 Jena, Germany
5 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Calgary, Calgary T2N 4N1, Canada
6 Department of Genetics, Alberta Children's Hospital, Calgary T2T 5C7, Canada

* To whom correspondence should be addressed.
R.H. Martin, E-mail: rhmartin{at}ucalgary.ca


  Abstract

BACKGROUND: Reciprocal translocations are often associated with infertility in male carriers. However, some carriers present normal semen profiles and are identified because of repetitive pregnancy failures. METHODS: Here, we report two different cases of reciprocal translocations. The first patient carried a t(10;14) and was normozoospermic. The second patient carried a t(13;20) and was azoospermic. Synaptonemal complexes from both carriers were analysed using immunocytogenetic techniques and multi-centromere fluorescent in situ hybridization (cenM-FISH). RESULTS: Associations between the quadrivalent and the sex body or other autosomes were seen only in the t(13;20) carrier. Heterosynapsis was observed only in the t(10;14) carrier. Synaptic pairing abnormalities were seen in 71% of the spreads in the t(13;20) carrier and 30% of the spreads in the t(10;14) carrier. Recombination frequency was decreased in the t(13;20) carrier, but not in the t(10;14) carrier. CONCLUSIONS: By comparing these two different translocation carriers with different fertility outcomes, we discuss the possible mechanisms by which translocations might cause the spermatogenesis process to fail.

Keywords: heterosynapsis; meiosis; meiotic checkpoints; reciprocal translocation; sex body.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
A. Pinton, A. Calgaro, N. Bonnet, S. Ferchaud, S. Billoux, A.M. Dudez, N. Mary, K. Massip, A. Bonnet-Garnier, M. Yerle, et al.
Influence of sex on the meiotic segregation of a t(13;17) Robertsonian translocation: a case study in the pig
Hum. Reprod., August 1, 2009; 24(8): 2034 - 2043.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. Kirkpatrick, K. A. Ferguson, H. Gao, S. Tang, V. Chow, B. H. Yuen, and S. Ma
A comparison of sperm aneuploidy rates between infertile men with normal and abnormal karyotypes
Hum. Reprod., July 1, 2008; 23(7): 1679 - 1683.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
R.H. Martin
Cytogenetic determinants of male fertility
Hum. Reprod. Update, June 4, 2008; (2008) dmn017v1.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. A. Ferguson, V. Chow, and S. Ma
Silencing of unpaired meiotic chromosomes and altered recombination patterns in an azoospermic carrier of a t(8;13) reciprocal translocation
Hum. Reprod., April 1, 2008; 23(4): 988 - 995.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
D. Homolka, R. Ivanek, J. Capkova, P. Jansa, and J. Forejt
Chromosomal rearrangement interferes with meiotic X chromosome inactivation
Genome Res., October 1, 2007; 17(10): 1431 - 1437.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. Sciurano, M. Rahn, G. Rey-Valzacchi, and A.J. Solari
The asynaptic chromatin in spermatocytes of translocation carriers contains the histone variant {gamma}-H2AX and associates with the XY body
Hum. Reprod., January 1, 2007; 22(1): 142 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Gutierrez-Mateo, J. Benet, H. Starke, M. Oliver-Bonet, S. Munne, T. Liehr, and J. Navarro
Karyotyping of human oocytes by cenM-FISH, a new 24-colour centromere-specific technique
Hum. Reprod., December 1, 2005; 20(12): 3395 - 3401.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.