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Hum. Reprod. Advance Access published online on March 3, 2005
Human Reproduction, doi:10.1093/humrep/deh740
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Human Reproduction © European Society of Human Reproduction and Embryology 2005; all rights reserved
Received April 16, 2004
Revised September 29, 2004
Accepted December 13, 2004

Article

The presence of functional mannose receptor on macrophages at the maternal-fetal interface

G. Laskarin 1*, K. Cupurdija 1, V. Sotosek Tokmadzic 1, D. Dorcic 1, J. Dupor 1, K. Juretic 1, N. Strbo 1, T. Bogovic Crncic 1, F. Marchezi 2, P. Allavena 2, A. Mantovani 2, Lj. Randic 3, and D. Rukavina 1

1 Department of Physiology and Immunology, School of Medicine, University of Rijeka, B. Branchetta 20/1, 51000 Rijeka, Croatia
2 Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
3 Department of Obstetrics and Gynaecology, Clinical Hospital Centre, University of Rijeka, Cambierrieva 42, 51000 Rijeka, Croatia and

* To whom correspondence should be addressed.
G. Laskarin, E-mail: Gordana.Laskarin{at}medri.hr


  Abstract

BACKGROUND: The mannose receptor (MR) is involved in the initiation of the immune response and regulation of homeostasis during inflammation and tissue remodeling. METHODS: Distribution, endocytosis and possible natural ligand tumor associated glycoprotein-72 (TAG-72) for the MR have been examined by immunohistology, immunocytochemistry and flow cytometry at the maternal-fetal interface, characterized by extensive tissue remodeling. RESULTS: Contrary to disseminated distribution of the MR positive (MR+) cells in term placenta, the MR+ cells of early pregnancy decidua intimately surrounded glands and followed tissue distribution of CD14 positive cells. The mannose receptor was present on freshly isolated first trimester decidual mononuclear cells and distributed mostly on macrophages (77.08 ± 10.55%, mean ± SD). The expression of the MR on CD14 positive cells decreased following 18 h culture (P<0.01) and was accompanied by the reduction of fluorescein isothiocyanate (FITC)-dextran uptake. PAM-1 anti-MR antibody, mannan and TAG-72 reduced FITC-dextran uptake by decidual macrophages. CONCLUSIONS: These data indicate that the MR+ macrophages, surrounding early decidual glands, are able to internalize ligands for carbohydrate recognition domain of the receptor, including decidual secretory phase mucin TAG-72.

Keywords: decidua; macrophages; mannose receptor; term pregnancy; tumor associated glycoprotein-72.
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