Skip Navigation



Hum. Reprod. Advance Access published online on February 3, 2005
Human Reproduction, doi:10.1093/humrep/deh768
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/6/1534    most recent
deh768v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Söderström-Anttila, V.
Right arrow Articles by Suikkari, A.-M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Söderström-Anttila, V.
Right arrow Articles by Suikkari, A.-M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction © European Society of Human Reproduction and Embryology 2005; all rights reserved
Received September 14, 2004
Revised December 20, 2004
Accepted January 10, 2005

Article

Favourable pregnancy results with insemination of in vitro matured oocytes from unstimulated patients

Viveca Söderström-Anttila 1*, Sirpa Mäkinen 1, Timo Tuuri 1, and Anne-Maria Suikkari 1

1 The Family Federation of Finland, Infertility Clinic, P.O. Box 849, 00101 Helsinki, Finland

* To whom correspondence should be addressed.
Viveca Söderström-Anttila, E-mail: viveca.soderstrom-anttila{at}vaestoliitto.fi


  Abstract

BACKGROUND: The purpose has been to develop an in vitro oocyte maturation (IVM) method for a wide range of patients. METHODS: A total of 239 cycles with immature oocyte retrieval (IOC) were carried out without hormonal priming. Patients with regular cycles and normal or polycystic ovaries (PCO) and anovulatory cycles with PCOS were included. Insemination or intracytoplasmic sperm injection (ICSI) according to sperm quality was alternatively used in fertilization of the matured oocytes. RESULTS: A total of 971 immature oocytes (mean 8.0±5.2) were collected in 122 IVM-IVF cycles and 851 oocytes (mean 7.3±4.4) in 117 IVM-ICSI cycles. The oocyte maturation and fertilization rate was 62.6% and 37.7% after insemination, and 53.9% and 69.3% after ICSI, respectively. The mean number of embryos transferred was 1.6. Clinical pregnancy rate per IOC was 23.8% in IVM-IVF and 17.1% in IVM-ICSI (ns). Implantation rate was higher in IVM-IVF (24.2%) than in IVM-ICSI (14.8%) (P<0.05). CONCLUSIONS: Insemination of IVM oocytes functions well, resulting in comparable pregnancy rates per IOC between IVM-IVF and IVM-ICSI. Good pregnancy results can be achieved both in patients with regular cycles and with PCO(S) by transferring only one or two embryos at a time.

Keywords: ICSI; in vitro maturation; IVF; PCOS; regular cycles.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
K. M. Lowther, V. N. Weitzman, D. Maier, and L. M. Mehlmann
Maturation, Fertilization, and the Structure and Function of the Endoplasmic Reticulum in Cryopreserved Mouse Oocytes
Biol Reprod, July 1, 2009; 81(1): 147 - 154.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
W.-Y. Son, J.-T. Chung, R.-C. Chian, B. Herrero, E. Demirtas, S. Elizur, Y. Gidoni, C. Sylvestre, N. Dean, and S. L. Tan
A 38 h interval between hCG priming and oocyte retrieval increases in vivo and in vitro oocyte maturation rate in programmed IVM cycles
Hum. Reprod., September 1, 2008; 23(9): 2010 - 2016.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
R Khoureiry, S Ibala-Rhomdane, L Mery, T Blachere, J-F Guerin, J Lornage, and A Lefevre
Dynamic CpG methylation of the KCNQ1OT1 gene during maturation of human oocytes
J. Med. Genet., September 1, 2008; 45(9): 583 - 588.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. DiLuigi, V. N. Weitzman, M. C. Pace, L. J. Siano, D. Maier, and L. M. Mehlmann
Meiotic Arrest in Human Oocytes Is Maintained by a Gs Signaling Pathway
Biol Reprod, April 1, 2008; 78(4): 667 - 672.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. von Wolff, T. Strowitzki, H. van der Ven, and M. Montag
In Vitro Maturation Is an Efficient Technique to Generate Oocytes and Should Be Considered in Combination With Cryopreservation of Ovarian Tissue for Preservation of Fertility in Women
J. Clin. Oncol., November 20, 2006; 24(33): 5336 - 5337.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
V. Soderstrom-Anttila, T. Salokorpi, M. Pihlaja, S. Serenius-Sirve, and A.-M. Suikkari
Obstetric and perinatal outcome and preliminary results of development of children born after in vitro maturation of oocytes
Hum. Reprod., June 1, 2006; 21(6): 1508 - 1513.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.