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Hum. Reprod. Advance Access published online on April 7, 2005
Human Reproduction, doi:10.1093/humrep/deh777
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Human Reproduction © European Society of Human Reproduction and Embryology 2005; all rights reserved
Received September 6, 2004
Accepted January 10, 2005

Article

Conservative treatment in epithelial ovarian cancer: results of a multicentre study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer) and SFOG (Société Française d'Oncologie Gynécologique)

Philippe Morice 1*, Eric Leblanc 2, Annie Rey 1, Marc Baron 3, Denis Querleu 4, Jérôme Blanchot 5, Pierre Duvillard 1, Catherine Lhommé 1, Damienne Castaigne 1, Jean Marc Classe 6, Pascal Bonnier 7, and GCCLCC 6, and and SFOG 7

1 Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
2 Centre Oscar Lambret, 3 rue Frédéric Combemale, 59020 Lille, France
3 Centre Henri Becquerel, Rue d'Amiens, 76038 Rouen, France
4 Institut Claudius Regaud, 20-24 rue du Pont Saint Pierre, 31052 Toulouse, France
5 Centre Eugene Marquis, Rue de la Bataille de Flandre Dunkerque, 35042 Rennes, France
6 Groupe des Chirurgiens de Centre de Lutte Contre le Cancer, France and
7 Société Française d'Oncologie Gynécologique, France

* To whom correspondence should be addressed.
Philippe Morice, E-mail: morice{at}igr.fr


  Abstract

BACKGROUND: Results of conservative management of epithelial ovarian cancer (EOC) remain controversial in the literature. The aim of this study was to assess the clinical outcomes and fertility following fertility-sparing surgical management of EOC in a retrospective multicentre study. METHODS: A multicentre retrospective study was performed by members of two French groups. Six inclusion criteria were defined: (i) Histological review by the same pathologist; (ii) age ≤40 years; (iii) conservative management; (iv) complete peritoneal staging; (v) delivery of a platinum-based chemotherapy in stage ≥IC; and (vi) follow-up >1 year. RESULTS: Thirty-four patients fulfilled the inclusion criteria: 30 had stage IA disease; three had stage IC and one had stage IIA. Eleven patients had recurrence: 10 patients had invasive disease and one had borderline recurrence. Among 10 patients with invasive recurrence, initial stage and grade were: stage IA G1, n=1; stage IA G2, n=4; stage IA G3, n=1; and stage≥IC, n=4. All patients with stage > IA had recurrence. Ten pregnancies were observed in nine patients. CONCLUSION: Conservative surgery for patients with EOC could be considered in young patients with stage IA G1 disease. This procedure should not be performed in patients with FIGO stage > IA.

Keywords: conservative surgery; epithelial ovarian tumour; pregnancy; recurrence; restaging surgery.
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