Skip Navigation



Hum. Reprod. Advance Access published online on March 31, 2005
Human Reproduction, doi:10.1093/humrep/deh846
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/7/2021    most recent
deh846v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Demirbag, S.
Right arrow Articles by Yesildaglar, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Demirbag, S.
Right arrow Articles by Yesildaglar, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received December 3, 2004
Revised January 28, 2005
Accepted February 12, 2005

Article

Comparison of hyaluronate/carboxymethylcellulose membrane and melatonin for prevention of adhesion formation in a rat model

Suzi Demirbag 1*, Salih Cetinkursun 2, Umut Tasdemir 3, Haluk Ozturk 2, Mesut Pekcan 4, and Narter Yesildaglar 5

1 Department of Paediatric Surgery and Research Centre,, Gülhane Military Medical Academy, Ankara, Turkey
2 Department of Paediatric Surgery and Research Centre, Gülhane Military Medical Academy, Ankara, Turkey
3 Lalahan Livestock Central Research Institute and Research Centre, Gülhane Military Medical Academy, Ankara, Turkey
4 Department of Surgery and Research Centre, Gülhane Military Medical Academy, Ankara, Turkey
5 Zübeyde Hn. Women's Hospital and Research Centre, Gülhane Military Medical Academy, Ankara, Turkey

* To whom correspondence should be addressed.
Suzi Demirbag, E-mail: sdemirbag{at}gata.edu.tr


  Abstract

BACKGROUND: To investigate the effectiveness of melatonin in preventing post-operative adhesion formation and to compare it with the efficacy of hyaluronate/carboxymethylcellulose membrane in a rat model. MATERIALS and METHODS: Following pilot studies, 35 rats were operated on in the full study. In 15 animals (group one), 10 standard lesions were inflicted in each uterine horn (total 30 horns) and melatonin was applied before closure of the abdomen. In the second group, 20 animals were operated on and one of the uterine horns (total 20 horns) with standard lesions was treated with hyaluronate/carboxymethylcellulose membrane and the other uterine horn served as a control. Second-look operations were performed 1 week later and adhesion scores were compared. RESULTS: The adhesion scores of uterine horns treated with melatonin and of uterine horns treated with hyaluronate/carboxymethylcellulose membrane were significantly lower than the scores of the controls (P<0.001). There was no statistically significant difference between the adhesion scores of uterine horns treated with melatonin and of uterine horns treated with hyaluronate/carboxymethylcellulose membrane (P>0.05). CONCLUSIONS: Both melatonin and hyaluronate/carboxymethylcellulose membrane were effective in prevention of adhesion formation in a rat uterine horn model.

Keywords: adhesion formation; hyaluronate-carboxymethylcellulose membrane/melatonin; surgical barriers/rat uterine horn model.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ICVTSHome page
M. Saeidi, R. Sobhani, M. Movahedi, S. Alsaeidi, and R. Eshraghi Samani
Effect of melatonin in the prevention of postoperative pericardial adhesion formation
Interactive CardioVascular and Thoracic Surgery, July 1, 2009; 9(1): 26 - 28.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.