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Hum. Reprod. Advance Access published online on May 5, 2005
Human Reproduction, doi:10.1093/humrep/dei039
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received September 22, 2004
Revised February 7, 2005
Accepted March 23, 2005

Article

Vasculogenesis in complete and partial hydatidiform mole pregnancies studied with CD34 immunohistochemistry

B.A.M. Lisman 1*, K. Boer 2, O.P. Bleker 2, M. van Wely 2, and N. Exalto 3

1 Department of Obstetrics and Gynaecology, Spaarne Ziekenhuis Haarlem, PO Box 1644, 2003 BR Haarlem, Netherlands and 2Department of Obstetrics and Gynaecology, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
2 Department of Obstetrics and Gynaecology, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
3 Department of Obstetrics and Gynaecology, Spaarne Ziekenhuis Haarlem, PO Box 1644, 2003 BR Haarlem, Netherlands and 2Department of Obstetrics and Gynaecology, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands

* To whom correspondence should be addressed.
B.A.M. Lisman, E-mail: B.A.Lisman{at}amc.uva.nl


  Abstract

BACKGROUND: Defective chorionic villous vascularization is present in pregnancies complicated by absent or abnormal embryonic development. The aim of this study was to investigate the embryonic and/or maternal genomic influence on vasculogenesis in diploid complete hydatidiform mole (CHM) and in triploid partial hydatidiform mole (PHM) in comparison with normal development. METHODS: Mean villous stromal area and functional vascular area, vessels with a lumen and haemangiogenetic cords, peripherally or centrally located were measured and counted in chorionic villi of 12 CHM, 12 normal pregnancies (termination of pregnancy, TOP) and 15 PHM of which nine were without an embryo (PHM-E) and six were with an embryo (PHM + E), using quantitative CD34 immunohistochemistry. RESULTS: TOP showed significantly more vessels per chorionic villus, centrally and peripherally located (median, range), than CHM, PHM-E and PHM + E (4.0, 0-9 versus 0.0, 0-11, 0.0, 0-18 and 1.0, 0-21). CHM showed significantly more centrally located cords than PHM-E, PHM + E and TOP (1.5, 0-22 versus 1.0, 0-15, 0.5, 0-8 and 1.0, 0-2). CONCLUSIONS: Initiation of chorionic villous vasculogenesis is independent of the maternal genome (CHM). The development of an embryo, however, is obligatory for the modulation of normal vascularization resulting in a well developed vasculosyncytial membrane.

Keywords: CD34; chorionic villous; complete hydatidiform mole; partial hydatidiform mole; vasculogenesis; triploidy.
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