Skip Navigation



Hum. Reprod. Advance Access published online on June 2, 2005
Human Reproduction, doi:10.1093/humrep/dei093
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/9/2402    most recent
dei093v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Doi, S. A.R.
Right arrow Articles by Al-Shoumer, K. A.S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Doi, S. A.R.
Right arrow Articles by Al-Shoumer, K. A.S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received January 24, 2005
Revised February 21, 2005
Accepted April 14, 2005

Article

Irregular cycles and steroid hormones in polycystic ovary syndrome

Suhail A.R. Doi 1*, Mona Al-Zaid 2, Philip A. Towers 3, Christopher J. Scott 3, and Kamal A.S. Al-Shoumer 1

1 Division of Endocrinology, Mubarak Al-Kabeer Hospital and Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait
2 Radioimmunoassay Laboratory, Mubarak Al-Kabeer Hospital, Kuwait
3 School of Biomedical Sciences, Charles Sturt University, Australia

* To whom correspondence should be addressed.
Suhail A.R. Doi, E-mail: sardoi{at}gmx.net


  Abstract

BACKGROUND: This cross-sectional study was undertaken to evaluate the factors that relate to menstrual status (oligo-amenorrhoea versus eumenorrhoea) in polycystic ovary syndrome (PCOS). METHODS: A total of 234 women with clinical and biochemical features suggestive of PCOS underwent metabolic and hormonal evaluation. A forward stepwise logistic regression model was created based on the results to determine variables related to ovulatory status. RESULTS: Only follicular phase progesterone and estradiol (E2) were retained in the final model. This model correctly classified 80% of PCOS women by ovulatory status. Univariate analysis revealed no difference in progesterone between ovulatory groups but E2 was higher in anovulatory groups. This suggested interaction between progesterone and E2 and the single interaction variable (progesterone/E2) also classified 80% of women by ovulatory status correctly. CONCLUSION: The results suggest that a low ratio of progesterone to E2 is associated with menstrual irregularity and ovulatory status in PCOS.

Keywords: estradiol; ovulation; polycystic ovaries; progesterone.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ReproductionHome page
V. Sander, C. G. Luchetti, M. E. Solano, E. Elia, G. Di Girolamo, C. Gonzalez, and A. B. Motta
Role of the N, N'-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone.
Reproduction, March 1, 2006; 131(3): 591 - 602.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.