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Hum. Reprod. Advance Access published online on May 26, 2005
Human Reproduction, doi:10.1093/humrep/dei098
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received December 25, 2004
Revised April 19, 2005
Accepted April 22, 2005

Article

The use of urine LH detection kits to time intrauterine insemination with donor sperm

Ahmad F. Khattab 1*, Fayez A. Mustafa 2, and Philip J. Taylor 2

1 Royal Oldham Hospital, Oldham OL1 2JH, UK
2 James Cook University Hospital, Middlesbrough TS4 3BW, UK

* To whom correspondence should be addressed.
Ahmad F. Khattab, E-mail: akhattabuk{at}hotmail.com


  Abstract

BACKGROUND: The study was carried out to determine the most likely time of day for the onset of the LH surge as detected using urine LH dipsticks, and to calculate the optimum time interval from the onset of the LH surge to intrauterine insemination (IUI). METHODS: A prospective study of 1540 cycles of IUI with donor sperm at Cleveland Fertility Centre, Middlesbrough, between June 1990 and February 2004. Only 951 cycles (where a positive urine LH dipstick result was immediately preceded by a negative result) were included in our study. To determine the best time interval between the onset of the LH surge and IUI, women were divided into five subgroups according to the positive urine test-IUI time interval and the pregnancy rate and live birth rate per cycle were calculated for each group. RESULTS: The first positive test was most frequently (44.5%) found at lunch-time (11:00-15:00). The live birth per cycle achieved was 5.6% when the insemination was performed 18-23 h from the first detection of the LH surge, and 11.7% when it was performed between 24 and 42 h. The live birth rate declined to 6.5% when IUI was performed later than that. Overall, no significant differences were discovered in live birth or pregnancy rate when insemination was performed at any of the time points between 18 and 53 h. CONCLUSION: Our study suggested that lunch-time is the best time to check for the LH surge using urine dipsticks and insemination at any time between 18 and 53 h after the onset of the surge will produce optimal results.

Keywords: donor insemination; intrauterine insemination; timing of LH surge; urine LH dipsticks.
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