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Hum. Reprod. Advance Access published online on May 19, 2005
Human Reproduction, doi:10.1093/humrep/dei109
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received May 4, 2004
Revised January 20, 2005
Accepted April 30, 2005

Case Report

Birth of a healthy infant after in vitro oocyte maturation and ICSI in a woman with diminished ovarian response: Case report

Barbro Fridén 1*, Julius Hreinsson 2, and Outi Hovatta 2

1 Department of Obstetrics and Gynaecology, Varberg Hospital, Varberg, Sweden
2 IVF Unit, Department of Clinical Science, Division of Obstetrics and Gynaecology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden

* To whom correspondence should be addressed.
Barbro Fridén, E-mail: barbro.friden{at}lthalland.se


  Abstract

In vitro maturation of oocytes (IVM) has been developed as a treatment option for subjects with good prognosis in assisted reproduction. We present successful IVM treatment in connection with a woman from whom low numbers of embryos were obtained after repeated failed conventional IVF cycles. A 35 year old woman, after 5 years infertility and two intrauterine insemination and three conventional IVF cycles, underwent first an IVM cycle with low dose FSH stimulation, and after failure, another natural IVM cycle. Three oocytes were obtained. After 36 h of IVM the oocytes had reached metaphase II stage, and fertilization using ICSI resulted in one 4-cell stage embryo, which was transferred 2 days later. The result was an uneventful pregnancy and birth of a healthy female infant weighing 4150 g. IVM may be an option for women from whom only low numbers of oocytes are obtained after gonadotrophin stimulation.

Keywords: diminished ovarian response; in vitro maturation; live birth; natural cycle.
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