Skip Navigation



Hum. Reprod. Advance Access published online on June 15, 2005
Human Reproduction, doi:10.1093/humrep/dei118
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/10/2769    most recent
dei118v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Sifer, C.
Right arrow Articles by Wolf, J.P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sifer, C.
Right arrow Articles by Wolf, J.P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received January 6, 2005
Revised April 27, 2005
Accepted April 29, 2005

Article

World Health Organization grade ‘a’ motility and zona-binding test accurately predict IVF outcome for mild male factor and unexplained infertilities

C. Sifer 1, T. Sasportes 1, V. Barraud 1, C. Poncelet 2, J. Rudant 3, R. Porcher 3, I. Cedrin-Durnerin 2, B. Martin-Pont 1, J.N. Hugues 2, and J.P. Wolf 1*

1 Service d’Histologie-Embryologie-Cytogénétique, Laboratoire de Biologie de la Reproduction
2 Service de Médecine de la Reproduction, Hôpital Jean Verdier, Assistance Publique - Hôpitaux de Paris, 93140 Bondy
3 Service de Biostatistique et d’Informatique Médicale, CHU Saint-Louis, Assistance Publique - Hôpitaux de Paris, 75475 Paris cedex 10, France

* To whom correspondence should be addressed.
J.P. Wolf, E-mail: jean-philippe.wolf{at}jvr.ap-hop-paris.fr


  Abstract

BACKGROUND: The aim of this study was to determine the pronostic value of a sperm-zona pellucida (ZP) binding assay, combined with World Health Organization (WHO) grade ‘a’ sperm motility on the day of the IVF attempt, to predict sperm fertilizing ability in unexplained and moderate male factor infertilities. METHODS: In total, 84 couples (64 unexplained infertility; 20 male factor) underwent both a sperm-ZP binding assay and an IVF attempt, irrespective of the test’s result. The test was negative when grade ‘a’ motility was ≤5% and/or the ZP binding index was <0.7. Fertilization and pregnancy rates were related to the test’s results. RESULTS: Thirty-one patients had a negative test (group N) and 53 a positive test (group P). A difference was observed concerning the fertilization rate [median (range): 0 (0-75%) versus 50 (0-100%); P = 0.0001] and the number of cycles with fertilization rate <20% (65 versus 23%; P = 0.0002) between groups N and P respectively. In the group of unexplained and male factor infertilities, the test showed a sensitivity of 83 and 60%, specificity of 50 and 90%, positive predictive value of 76 and 86%, and negative predictive value of 61 and 69% respectively. CONCLUSION: Sperm-ZP binding test, combined with WHO grade ‘a’ motility assessment, is relevant to prevent IVF fertilization failures in unexplained infertility and, most particularly, in moderate male factor infertility.

Keywords: IVF/fertilization rate/pregnancy rate/sperm-zona pellucida binding assay/sperm motility.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
D. Y. Liu, M. L. Liu, C. Garrett, and H.W. G. Baker
Comparison of the frequency of defective sperm-zona pellucida (ZP) binding and the ZP-induced acrosome reaction between subfertile men with normal and abnormal semen
Hum. Reprod., July 1, 2007; 22(7): 1878 - 1884.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. L.H. Evers
WHO grade 'a' sperm motility and zona pellucida-binding test predict IVF outcome
Hum. Reprod., January 1, 2007; 22(1): 311 - 311.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Sifer, C. Poncelet, R. Porcher, and J.P. Wolf
Reply: WHO grade 'a' sperm motility and zona pellucida-binding test predict IVF outcome
Hum. Reprod., January 1, 2007; 22(1): 311 - 312.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
H. Ye, G.-n. Huang, Y. Gao, and D. Y. Liu
Relationship between human sperm-hyaluronan binding assay and fertilization rate in conventional in vitro fertilization
Hum. Reprod., June 1, 2006; 21(6): 1545 - 1550.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.