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Hum. Reprod. Advance Access published online on July 15, 2005
Human Reproduction, doi:10.1093/humrep/dei141
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received December 8, 2004
Revised April 11, 2005
Accepted April 19, 2005

Article

Fecundability according to male serum inhibin B--a prospective study among first pregnancy planners

L.M. Mabeck 1*, M.S. Jensen 1, G. Toft 1, M. Thulstrup 1, M. Andersson 2, T.K. Jensen 3, A. Giwercman 4, J. Olsen 5, J.P. Bonde 1, and The Danish First Pregnancy Planners Study Team

1 Department of Occupational Medicine, University Hospital of Aarhus, Aarhus Sygehus, Norrebrogade 44, building 2C, DK-8000 Aarhus C, Denmark
2 Department of Growth and Reproduction, National University Hospital, Rigshospitalet, section GR 5064, Blegdamsvej 9, DK-2100 Copenhagen
3 Department of Environmental Medicine, University of Southern Denmark, Winslowparken 17, DK-5000 Odense C, Denmark
4 Scanian Andrology Centre, Malmö University Hospital, SE 205 02 Malmö, Sweden
5 Danish Epidemiology Sciences Centre, University of Aarhus, Vennelyst Boulevard 6, build. 260, DK-8000 Aarhus C, Denmark

* To whom correspondence should be addressed.
L.M. Mabeck, E-mail: anemt{at}akh.aaa.dk


  Abstract

BACKGROUND: New biological markers of male fecundity are needed for use in large-scale epidemiological studies. We studied the association between male inhibin B and fecundability. METHODS: Four hundred and thirty Danish couples without previous reproductive experience were followed from termination of contraception until pregnancy or for a maximum of six menstrual cycles. At enrolment we obtained semen samples (n = 418) and blood samples to measure reproductive hormones, including inhibin B (n = 343). RESULTS: The fecundability odds ratio for an increment of male inhibin B by 1 log pg/ml was 1.428 (95% confidence interval 1.022-1.994), adjusted for factors influencing the crude estimate. Only inhibin B values below 100 pg/ml were strongly related to fecundability. We designed a receiver operating characteristic curve based on the 29 males with serum inhibin B ≤100 pg/ml. The area under the curve (AUC) for inhibin B was 0.787 and the corresponding AUCs for sperm density and FSH were 0.913 and 0.800, respectively. CONCLUSION: Serum inhibin B may be a reliable marker of male fecundity for epidemiological research and may have some advantages over sperm density. Our findings do not support the replacement of sperm density by male inhibin B when obtaining sperm data is an option.

Keywords: fertility/male reproduction/inhibins/sperm density/time to pregnancy.
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