Skip Navigation



Hum. Reprod. Advance Access published online on June 24, 2005
Human Reproduction, doi:10.1093/humrep/dei146
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/10/2904    most recent
dei146v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hoon Kim, S.
Right arrow Articles by Yong Moon, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoon Kim, S.
Right arrow Articles by Yong Moon, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received February 15, 2005
Revised May 13, 2005
Accepted May 19, 2005

Article

Vascular endothelial growth factor gene +405 C/G polymorphism is associated with susceptibility to advanced stage endometriosis

Sung Hoon Kim 1, Young Min Choi 2*, Seon Ha Choung 3, Jong Kwan Jun 3, Jung Gu Kim 3, and Shin Yong Moon 2

1 Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center
2 Department of Obstetrics and Gynecology and The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Korea
3 Department of Obstetrics and Gynecology


  Abstract

BACKGROUND: Vascular endothelial growth factor (VEGF) is known to play a pivotal role in the development of endometriosis. This study was performed to investigate whether the VEGF gene 5’-untranslated region polymorphism is associated with susceptibility to advanced stage endometriosis. METHODS: This study comprised 215 women with advanced stage endometriosis, 219 control women without endometriosis, and 70 fertile women. Following extraction of genomic DNA, genotyping of the -460 C/T and +405 C/G polymorphisms of the VEGF gene were performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS: The distribution of genotypes and allele frequencies of the -460 C/T polymorphism in the endometriosis group did not differ from those in the control group and the fertile women group. However, genotype distribution of the +405 C/G polymorphism was significantly different between patients with and without endometriosis (P = 0.01) and between patients with endometriosis and the fertile women (P = 0.02). Patients with endometriosis showed a higher incidence of the +405 CC genotype compared with the controls and the fertile women (P = 0.007 and 0.016 respectively). CONCLUSIONS: These findings suggest that the VEGF +405 C/G polymorphism may be associated with the risk of advanced stage endometriosis in the Korean population.

Keywords: angiogenesis/endometriosis/polymorphism/VEGF.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
Q. Liu, Y. Li, J. Zhao, D.-L. Sun, Y.-N. Duan, N. Wang, R.-M. Zhou, and S. Kang
Association of polymorphisms -1154G/A and -2578C/A in the vascular endothelial growth factor gene with decreased risk of endometriosis in Chinese women
Hum. Reprod., October 1, 2009; 24(10): 2660 - 2666.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H. Kim, S. Y. Ku, S. H. Kim, G. H. Lee, Y. M. Choi, J. M. Kim, T. H. Lee, and S. Y. Moon
Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with advanced stage endometriosis
Hum. Reprod., October 1, 2009; 24(10): 2656 - 2659.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H. Xu, W.T. Lui, C.Y. Chu, P.S. Ng, C.C. Wang, and M.S. Rogers
Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model
Hum. Reprod., March 1, 2009; 24(3): 608 - 618.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
R. N. Taylor, Jie Yu, P. B. Torres, A. C. Schickedanz, J. K. Park, M. D. Mueller, and N. Sidell
Mechanistic and Therapeutic Implications of Angiogenesis in Endometriosis
Reproductive Sciences, February 1, 2009; 16(2): 140 - 146.
[Abstract] [PDF]

Home page
 Hum Reprod UpdateHome page
C.B. Tempfer, M. Simoni, B. Destenaves, and B.C.J.M. Fauser
Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis
Hum. Reprod. Update, January 1, 2009; 15(1): 97 - 118.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
Z. Z. Zhao, D. R. Nyholt, S. Thomas, S. A. Treloar, and G. W. Montgomery
Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis
Mol. Hum. Reprod., September 1, 2008; 14(9): 531 - 538.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
D. Gentilini, E. Somigliana, P. Vigano, M. Vignali, M. Busacca, and A. M. Di Blasio
The vascular endothelial growth factor +405G>C polymorphism in endometriosis
Hum. Reprod., January 1, 2008; 23(1): 211 - 215.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. K. Tee, J.-L. Vigne, and R. N. Taylor
All-Trans Retinoic Acid Inhibits Vascular Endothelial Growth Factor Expression in a Cell Model of Neutrophil Activation
Endocrinology, March 1, 2006; 147(3): 1264 - 1270.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.