Skip Navigation



Hum. Reprod. Advance Access published online on June 24, 2005
Human Reproduction, doi:10.1093/humrep/dei150
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/10/2887    most recent
dei150v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kolibianakis, E.M.
Right arrow Articles by Griesinger, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kolibianakis, E.M.
Right arrow Articles by Griesinger, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received January 16, 2005
Revised April 11, 2005
Accepted April 20, 2005

Article

A lower ongoing pregnancy rate can be expected when GnRH agonist is used for triggering final oocyte maturation instead of HCG in patients undergoing IVF with GnRH antagonists

E.M. Kolibianakis 1*, A. Schultze-Mosgau 2, A. Schroer 2, A. van Steirteghem 1, P. Devroey 1, K. Diedrich 2, and G. Griesinger 1

1 Centre of Reproductive Medicine, Dutch-Speaking Brussels Free University, B-1090, Brussels, Belgium
2 Department of Gynecology and Obstetrics, Division of Gynaecological Endocrinology and Reproductive Medicine, University Clinic of Schleswig-Holstein, Campus Lübeck, 23538 Lübeck, Germany

* To whom correspondence should be addressed.
E.M. Kolibianakis, E-mail: stratis.kolibianakis{at}otenet.gr


  Abstract

BACKGROUND: Eliciting an endogenous LH surge by GnRH-agonist for the induction of final oocyte maturation may be more physiological compared with the administration of HCG. However, the efficacy of this intervention in patients treated for IVF with GnRH antagonists remains to be assessed. METHODS: 106 patients were randomized to receive either 10 000 IU urinary HCG or 0.2 mg Triptorelin for triggering final oocyte maturation. Ovarian stimulation for IVF was performed with a fixed dose of 200 IU recombinant FSH and GnRH antagonist was started on stimulation day 6. Luteal phase was supported with micronized vaginal progesterone and oral estradiol. The study was monitored continuously for safety and stopping rules were established. RESULTS: No significant differences were present in the number of cumulus-oocyte complexes retrieved, in the proportion of metaphase II oocytes, in fertilization rates or in the number and quality of the embryos transferred between the two groups. However, a significantly lower probability of ongoing pregnancy in the GnRH agonist arm prompted discontinuation of the trial, according to the stopping rules established (odds ratio 0.11; 95% confidence interval 0.02-0.52). CONCLUSIONS: Lower probability of ongoing pregnancy can be expected when GnRH agonist is used for triggering final oocyte maturation instead of HCG in patients undergoing ovarian stimulation for IVF with GnRH antagonists.

Keywords: HCG versus GnRH agonist/IVF-GnRH antagonist cycles/ongoing pregnancy rates/oocyte maturation/RCT.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
G. Griesinger, S. von Otte, A. Schroer, A.K. Ludwig, K. Diedrich, S. Al-Hasani, and A. Schultze-Mosgau
Elective cryopreservation of all pronuclear oocytes after GnRH agonist triggering of final oocyte maturation in patients at risk of developing OHSS: a prospective, observational proof-of-concept study
Hum. Reprod., May 1, 2007; 22(5): 1348 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
U.-H. Stenman, A. Tiitinen, H. Alfthan, and L. Valmu
The classification, functions and clinical use of different isoforms of HCG
Hum. Reprod. Update, November 1, 2006; 12(6): 769 - 784.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Y. Andersen, P. Humaidan, H. B. Ejdrup, L. Bungum, M.L. Grondahl, and L.G. Westergaard
Hormonal characteristics of follicular fluid from women receiving either GnRH agonist or hCG for ovulation induction
Hum. Reprod., August 1, 2006; 21(8): 2126 - 2130.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
B.C. Tarlatzis, B.C. Fauser, E.M. Kolibianakis, K. Diedrich, P. Devroey, and , On Behalf of the Brussels GnRH Antagonist Consen
GnRH antagonists in ovarian stimulation for IVF
Hum. Reprod. Update, July 1, 2006; 12(4): 333 - 340.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Pirard, J. Donnez, and E. Loumaye
GnRH agonist as luteal phase support in assisted reproduction technique cycles: results of a pilot study
Hum. Reprod., July 1, 2006; 21(7): 1894 - 1900.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E.M. Kolibianakis, P. Devroey, K. Diedrich, and G. Griesinger
Reply: 'GnRH agonist trigger: looking for the coin under the lamp post?'
Hum. Reprod., May 1, 2006; 21(5): 1328 - 1329.
[Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
S. Kol
Agonist trigger in the context of OHSS prevention: primum non nocere
Hum. Reprod. Update, May 1, 2006; 12(3): 327 - 328.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
R. Babayof, E. J. Margalioth, M. Huleihel, A. Amash, E. Zylber-Haran, M. Gal, B. Brooks, T. Mimoni, and T. Eldar-Geva
Serum inhibin A, VEGF and TNF{alpha} levels after triggering oocyte maturation with GnRH agonist compared with HCG in women with polycystic ovaries undergoing IVF treatment: a prospective randomized trial
Hum. Reprod., May 1, 2006; 21(5): 1260 - 1265.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
G. Griesinger, K. Diedrich, P. Devroey, and E.M. Kolibianakis
GnRH agonist for triggering final oocyte maturation in the GnRH antagonist ovarian hyperstimulation protocol: a systematic review and meta-analysis
Hum. Reprod. Update, March 1, 2006; 12(2): 159 - 168.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.