Skip Navigation



Hum. Reprod. Advance Access published online on June 24, 2005
Human Reproduction, doi:10.1093/humrep/dei154
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/10/2958    most recent
dei154v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Cagnur Ulukus, E.
Right arrow Articles by Arici, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cagnur Ulukus, E.
Right arrow Articles by Arici, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received January 5, 2005
Revised May 11, 2005
Accepted May 13, 2005

Article

Expression of interleukin-8 and monocyte chemotactic protein-1 in adenomyosis

E. Cagnur Ulukus 1, Murat Ulukus 2, Yasemin Seval 3, Wenxin Zheng 4, and Aydin Arici 5*

1 Yale University School of Medicine, Department of Pathology, New Haven, CT, USA; Dokuz Eylul University School of Medicine, Department of Pathology, Inciralti, Izmir
2 Yale University School of Medicine, Departments of Obstetrics and Gynecology, New Haven, CT, USA; Ege University School of Medicine, Department of Obstetrics & Gynecology, Bornova, Izmir
3 Yale University School of Medicine, Departments of Obstetrics and Gynecology, New Haven, CT, USA; Akdeniz University School of Medicine, Department of Histology and Embryology, Antalya, Turkey
4 Yale University School of Medicine, Department of Pathology, New Haven, CT, USA
5 Yale University School of Medicine, Departments of Obstetrics and Gynecology, New Haven, CT, USA

* To whom correspondence should be addressed.
Aydin Arici, E-mail: aydin.arici{at}yale.edu


  Abstract

BACKGROUND: To clarify the inflammatory nature of adenomyosis, we aimed to investigate the expression of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) by immunohistochemistry to determine their putative role in pathophysiology of adenomyosis. METHODS: Adenomyosis samples, with their eutopic endometrium, were collected from 30 women undergoing hysterectomy. Endometrium from 27 women without adenomyosis were also collected as a control group. Samples were grouped according to the menstrual cycle phase and examined by immunohistochemistry for IL-8 and MCP-1. RESULTS: In normal endometrium, secretory phase samples expressed higher levels of epithelial IL-8 than in proliferative phase samples (P = 0.01), and we observed a trend for an increased epithelial MCP-1 expression in the secretory phase samples compared with the proliferative phase samples (P = 0.07). Endometrial samples of women with adenomyosis did not show the same cyclic variation. In the secretory phase, eutopic endometrium of women with adenomyosis expressed lower levels of epithelial IL-8 and MCP-1 compared with normal endometrium (P < 0.05). The expression of epithelial IL-8 and MCP-1 was higher in the adenomyosis foci than the eutopic endometrium (P < 0.05). CONCLUSIONS: These findings may indicate that an intrinsic abnormality of inflammatory response may be present in eutopic endometrium of women with adenomyosis, and IL-8 and MCP-1 may contribute to the pathophysiology of adenomyosis.

Keywords: adenomyosis/endometriosis/endometrium/interleukin-8/monocyte chemotactic protein-1.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 EndocrinologyHome page
R. M. Popovici, N. K. Betzler, M. S. Krause, M. Luo, J. Jauckus, A. Germeyer, S. Bloethner, A. Schlotterer, R. Kumar, T. Strowitzki, et al.
Gene Expression Profiling of Human Endometrial-Trophoblast Interaction in a Coculture Model
Endocrinology, December 1, 2006; 147(12): 5662 - 5675.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.