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Hum. Reprod. Advance Access published online on July 21, 2005
Human Reproduction, doi:10.1093/humrep/dei195
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received March 28, 2005
Revised June 6, 2005
Accepted June 15, 2005

Article

Fertilization, cleavage and blastocyst development according to the maturation timing of oocytes in in vitro maturation cycles*

Weon-Young Son 1*, Seok-Yoon Lee 1, and Jin-Ho Lim 1

1 Maria Infertility Hospital, Sinseol-dong, Dongdaemun-gu, Seoul 121-742, Korea

* To whom correspondence should be addressed.
Weon-Young Son, E-mail: weon-young.son{at}muhc.mcgill.ca


  Abstract

BACKGROUND: This study was to examine the developmental capacity of oocytes collected from an in vitro matura-tion (IVM) programme according to their maturation time. METHODS: The study included 47 IVM cycles that underwent blastocyst transfer. The patients (n = 38) were primed with 10 000 IU HCG 36 h before their oocyte retrieval. The oocytes were classified into three groups: group 1 (n = 139) where oocytes were matured on day of oocyte collection; group 2 (n =627) where oocytes were matured on day 1 after IVM; group 3 (n = 163) where oocytes matured on day 2 after IVM. Fertilization, cleavage and blastocyst formation were compared between three groups. RESULTS: Rates of cleavage and blastocyst development in group 3 (72.2%, 96/133; 19.0%, 15/133) were significantly lower than those of group 1 (100%, 108/108; 58.3%, 63/108) and group 2 (91.5%, 487/532; 50.4%, 268/532) respectively (P < 0.01). The number of freezable good quality blastocysts among blastocysts developed from group 1 (52.4%, 33/63) was significantly higher than those from group 2 (35.4%, 95/268) and group 3 (6.7%, 1/15) (P < 0.01). There were 24 clinical pregnancies (51.1%, 24/47) after transfer of the blastocysts and 29 healthy babies were delivered. CONCLUSION: These results suggest that oocytes reaching metaphase II faster in an IVM programme have better embryonic developmental competence.

Keywords: blastocyst/HCG/immature oocytes/IVM/maturation time.
*Presented at the Annual Meeting of the European Society of Human Reproduction and Embryology, Vienna, Austria, June 30-July 3, 2002.
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