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Hum. Reprod. Advance Access first published online on July 8, 2005
This version published online on July 19, 2005
Human Reproduction, doi:10.1093/humrep/dei197
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received April 16, 2005
Revised June 12, 2005
Accepted June 16, 2005

Opinion

Human embryonic stem cell lines are contaminated: what should we do?

Wei-Hua Wang 1* and Xiao-Fang Sun 2

1 In Vitro Fertilization Laboratory, Tomball Regional Hospital, TX 77375, USA and Institute of Obstetrics and Gyncology, Guangzhou Second People’s Hospital, Guangzhou, China
2 Institute of Obstetrics and Gyncology, Guangzhou Second People’s Hospital, Guangzhou, China

* To whom correspondence should be addressed.
Wei-Hua Wang, E-mail: wangweihua11{at}yahoo.com


  Abstract

Human embryonic stem (hES) cells have the potential to differentiate into any desired cells and to be used in cell replacement therapies for some diseases. However, existing hES cell lines would not be suitable for the therapies as they are contaminated with other biological products. In order to produce the safest hES cell lines for therapeutic purposes, all steps for the establishment of hES cell lines must avoid the use of animal serum and/or animal feeder cell lines. Safe and fast approaches to producing hES cell lines based on recent research advances in both humans and animals have been suggested.

Keywords: contamination/embryonic stem cells/human/IVF/safety.
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