Skip Navigation



Hum. Reprod. Advance Access published online on July 21, 2005
Human Reproduction, doi:10.1093/humrep/dei205
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/11/3184    most recent
dei205v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Villuendas, G.
Right arrow Articles by San Millán, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Villuendas, G.
Right arrow Articles by San Millán, J. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received February 27, 2005
Revised May 17, 2005
Accepted June 16, 2005

Article

Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls

Gemma Villuendas 1, José I. Botella-Carretero 1, Belén Roldán 2, José Sancho 2, Héctor F. Escobar-Morreale 2*, and José L. San Millán 3

1 Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain; These authors contributed equally to this work
2 Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain
3 Department of Molecular Genetics, Hospital Ramón y Cajal, Madrid, Spain

* To whom correspondence should be addressed.
Héctor F. Escobar-Morreale, E-mail: hescobarm.hrc{at}salud.madrid.org


  Abstract

BACKGROUND: We aimed to evaluate the influence of the Gly972Arg variant of the insulin receptor substrate-1 gene (IRS-1) and the Gly1057Asp variant in IRS-2 on insulin resistance and glucose tolerance in women with polycystic ovary syndrome (PCOS) and healthy controls. METHODS: Genotypes, allelic frequencies, indexes of insulin resistance, glucose tolerance and hormone profiles were studied in a large sample of Spanish PCOS (n = 103) women compared with a control group (n = 48) of healthy women matched for body mass index. RESULTS: No differences in genotype or allelic frequencies were found between PCOS patients and healthy controls. When considering control subjects and PCOS patients as a whole, IRS-1 Arg972 carriers also presented with increased fasting insulin (133 ± 60 versus 95 ± 67 pmol/l, P = 0.008) and insulin resistance measured by homeostasis model assessment (4.3 ± 2.1 versus 3.1 ± 2.4, P = 0.009) compared with subjects homozygous for Gly972 alleles. These differences were even higher when restricting the analysis to PCOS patients. Subjects homozygous for the Gly1057 allele of IRS-2 presented with increased 60 and 90 min oral glucose tolerance test (OGTT) glucose levels compared with carriers of one or two Asp1057 alleles (7.9 ± 2.1 versus 7.1 ± 2.1 mmol/l, P = 0.042 and 7.0 ± 2.1 versus 6.0 ± 1.8 mmol/l, P = 0.014), and a similar tendency was observed for 120 min OGTT glucose levels. CONCLUSIONS: The Gly972Arg in IRS-1 and Gly1057Asp in IRS-2 polymorphisms influence glucose homeostasis in premenopausal women, but are not associated with PCOS.

Keywords: insulin resistance/insulin-receptor substrate/polycystic ovary syndrome/polymorphisms.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur J EndocrinolHome page
V. Koika, D. J Marioli, A. D Saltamavros, V. Vervita, K. D Koufogiannis, G. Adonakis, G. Decavalas, and N. A Georgopoulos
Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor {gamma}2 with decreased basic metabolic rate in women with polycystic ovary syndrome
Eur. J. Endocrinol., August 1, 2009; 161(2): 317 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
M. Simoni, C.B. Tempfer, B. Destenaves, and B.C.J.M. Fauser
Functional genetic polymorphisms and female reproductive disorders: Part I: polycystic ovary syndrome and ovarian response
Hum. Reprod. Update, September 1, 2008; 14(5): 459 - 484.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. L. San Millan, F. Alvarez-Blasco, M. Luque-Ramirez, J. I. Botella-Carretero, and H. F. Escobar-Morreale
The PON1-108C/T polymorphism, and not the polycystic ovary syndrome, is an important determinant of reduced serum paraoxonase activity in premenopausal women
Hum. Reprod., December 1, 2006; 21(12): 3157 - 3161.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
F. Alvarez-Blasco, J. I. Botella-Carretero, J. L. San Millan, and H. F. Escobar-Morreale
Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women.
Arch Intern Med, October 23, 2006; 166(19): 2081 - 2086.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H.F. Escobar-Morreale, G. Villuendas, J.I. Botella-Carretero, F. Alvarez-Blasco, R. Sanchon, M. Luque-Ramirez, and J.L. San Millan
Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study
Hum. Reprod., September 1, 2006; 21(9): 2257 - 2265.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.