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Hum. Reprod. Advance Access published online on August 5, 2005
Human Reproduction, doi:10.1093/humrep/dei221
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received May 14, 2005
Revised June 17, 2005
Accepted June 29, 2005

Article

Metabolic syndrome in young Czech women with polycystic ovary syndrome

J. Vrbíková 1*, K. Vondra 1, D. Cibula 2, K. Dvoráková 1, S. Stanická 1, D. Srámková 1, G. Sindelka 3 {dagger}, M. Hill 1, B. Bendlová 1, and J. Skrha 3

1 Institute of Endocrinology, Národní 8, Prague 1, 116 94 Czech Republic
2 Department of Obstetrics and Gynecology, Charles University, Apolinárská 28, Prague 2, 120 00 Czech Republic
3 Department of Internal Medicine, Charles University, U Nemocnice 1, Prague 2, 120 00 Czech Republic

* To whom correspondence should be addressed.
J. Vrbíková, E-mail: jvrbikova{at}endo.cz


  Abstract

METHODS: Sixty-nine young women with polycystic ovary syndrome (PCOS) [age 25.2 ± 4.7 years, with body mass index (BMI) 24.3 ± 4.8 kg/m2; mean ± SD] and 73 age-matched healthy females (BMI 22.3 ± 3.3 kg/m2; mean ± SD) were evaluated for the occurrence of features of metabolic syndrome according to the Adult Treatment Panel III. RESULTS: Overt metabolic syndrome (the presence of three and more risk factors) was not more common in PCOS women (1/64, 1.6%) than in healthy controls (0/73, 0%). On the other hand, in nearly 50% of PCOS women isolated features of metabolic syndrome, most often a decrease in high-density lipoprotein (HDL) cholesterol, were found. Women with at least one feature of metabolic syndrome were, in comparison with women without any of these features, significantly more obese (P = 0.0001), with lower insulin sensitivity (P = 0.05). When comparing PCOS women according to the degree of insulin sensitivity, as determined by euglycaemic clamp, isolated features of metabolic syndrome were found in 8/17 women above the upper quartile, compared with 11/16 women below the lower quartile of insulin sensitivity (P = 0.20). CONCLUSIONS: Overt metabolic syndrome is only rarely encountered in young Czech females affected by PCOS but its isolated features are relatively frequent, both in young PCOS patients and in age-matched control women.

Keywords: euglycaemic clamp/insulin resistance/metabolic syndrome/polycystic ovary.
{dagger}Dr Gustav Sindelka died in 2001.
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