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Hum. Reprod. Advance Access published online on July 29, 2005
Human Reproduction, doi:10.1093/humrep/dei233
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received May 24, 2005
Revised June 26, 2005
Accepted July 5, 2005

Article

Serum adiponectin concentrations are decreased in women with endometriosis

Yuri Takemura 1, Yutaka Osuga 1*, Miyuki Harada 1, Tetsuya Hirata 1, Kaori Koga 1, Chieko Morimoto 1, Yasushi Hirota 1, Osamu Yoshino 1, Tetsu Yano 1, and Yuji Taketani 1

1 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

* To whom correspondence should be addressed.
Yutaka Osuga, E-mail: yutakaos-tky{at}umin.ac.jp


  Abstract

BACKGROUND: Adiponectin is a pleiotropic cytokine originally discovered as an adipocyte-specific gene product. Serum adiponectin concentrations have been reported to be low in women with endometrial cancer, breast cancer and uterine leiomyoma, suggesting possible involvement of adiponectin in these estrogen-related diseases. We thus addressed the relevance of adiponectin to endometriosis, an estrogen-dependent disease, in the present study. METHODS: Women with (n = 48) and without (n = 30) endometriosis undergoing laparoscopy were recruited in this study. Blood samples were collected, and serum adiponectin concentrations were measured using a specific enzyme-linked immunosorbent assay. The relationship between laparoscopic findings and serum adiponectin concentrations was analysed. RESULTS: The adiponectin concentrations in the serum of the women with endometriosis (median, 13.1 µg/ml; interquartile range, 10.2-16.7) were significantly lower than those of the women without endometriosis (15.9 µg/ml, 13.5-19.5; P = 0.008). A significant negative correlation was found between serum adiponectin concentrations and both endometriosis scores (R = - 0.307, P = 0.006) and adhesion scores (R = - 0.254, P = 0.026) of the revised American Society for Reproductive Medicine classification of endometriosis. CONCLUSIONS: The present findings suggest that adiponectin is implicated in the pathophysiology of endometriosis.

Keywords: adiponectin/endometriosis.
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