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Hum. Reprod. Advance Access published online on September 9, 2005
Human Reproduction, doi:10.1093/humrep/dei280
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received May 17, 2005
Revised June 22, 2005
Accepted July 4, 2005

Article

Number of germ cells and somatic cells in human fetal ovaries during the first weeks after sex differentiation

E. Bendsen 1*, A.G. Byskov 2, C.Yding Andersen 2, and L.G. Westergaard 1

1 Fertility Clinic, Department of Obstetrics and Gynaecology, University Hospital of Odense, Sdr. Boulevard 29, 5000 Odense C, Denmark
2 Laboratory of Reproductive Biology, Juliane Marie Center for Children, Women and Reproduction, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark

* To whom correspondence should be addressed.
E. Bendsen, E-mail: e.bendsen{at}dadlnet.dk


  Abstract

BACKGROUND: This study presents the number of germ cells and somatic cells in human fetal ovaries during week 6 to week 9 post conception, i.e. the first weeks following sex differentiation of the gonads. METHODS: One ovary with attached mesonephros from each of 11 individual legal abortions was used for estimation of cell numbers. After recovery of the fetus, the ovary-mesonephric complexes were immediately isolated, fixed and processed for histology. A stereological method was utilized to estimate the total number of oogonia in all ovaries and somatic cells in seven of them. RESULTS: The number of oogonia per ovary increased from ~26 000 in week 6 to ~250 000 in week 9 and somatic cells from ~240 000 to ~1.4x106. The ratio of oogonia to somatic cells tended to increase throughout the period. The concentration of oogonia was similar in the cranial (mesonephric connected) part and the caudal part of the ovaries. CONCLUSIONS: This is the first stereological estimation of the number of oogonia and somatic cells in human fetal ovaries, and the first estimation of germ cells and somatic cells in ovaries aged <9 weeks. The number of oogonia in week 9 is comparable to the numbers previously published based on non-stereological estimations. We found early stages of meiosis in fetal ovaries from week 9.

Keywords: fetal ovaries/first trimester/germ cells/human/in vivo.
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