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Hum. Reprod. Advance Access published online on September 9, 2005
Human Reproduction, doi:10.1093/humrep/dei284
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received December 19, 2004
Revised July 18, 2005
Accepted July 18, 2005

Article

Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS?

Polat Dursun 1, Ezgi Demirtas 1, Ahmet Bayrak 2, and Hakan Yarali 3*

1 Department of Obstetrics & Gynecology, Hacettepe University, Ankara, Turkey
2 Department of Biochemistry, School of Medicine, Hacettepe University, Ankara, Turkey
3 Departments of Obstetrics & Gynecology, Hacettepe University, Ankara, Turkey

* To whom correspondence should be addressed.
Hakan Yarali, E-mail: yarali{at}ada.net.tr or hyarali@hacettepe.edu.tr


  Abstract

BACKGROUND: Patients with polycystic ovary syndrome (PCOS) may have an increased risk for the development of hypertension and atherosclerotic heart disease (AHD), the pathophysiological mechanisms of which are not clear. Paraoxonase1 (PON1) is a high-density lipoprotein-associated enzyme that prevents oxidative modification of low-density lipoprotein. The aim of this study was to measure the serum levels of PON1 activity in patients with PCOS and to compare with those of regularly cycling controls. METHODS: Serum lipid parameters, malondialdehyde (MDA) levels and PON1 activity, were measured in PCOS patients (n = 23) and regularly cycling, age-, body mass index- and smoking status-matched controls (n = 23). All patients had normal glucose tolerance test as assessed by a 75 g oral glucose tolerance test. None of the patients had clinically evident hypertension or AHD. RESULTS: Apart from the mean serum PON1 activity, all parameters in the lipid profile including serum MDA levels were comparable between the two groups. There were no significant differences in respect to fasting glucose (4.64 ± 0.5 versus 4.43 ± 0.83 mmol/l) and fasting glucose insulin ratio (11.06 ± 8.26 versus 11.49 ± 4.90) among the two groups (P > 0.05). However, HOMA insulin resistance index was significantly higher in patients with PCOS compared with the controls (2.06 ± 0.86 versus 1.51 ± 0.49; P = 0.01). Also, mean serum PON1 activity was significantly lower in the PCOS group compared with the controls (151.2 ± 90.8 versus 217.7 ± 101.6, respectively; P = 0.027). CONCLUSIONS: Reduced serum PON1 activity might contribute to the increased susceptibility for the development of AHD in women with PCOS.

Keywords: atherosclerotic heart disease/cardiovascular disease/insulin resistance/paraoxonase/polycystic ovary syndrome.
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The PON1-108C/T polymorphism, and not the polycystic ovary syndrome, is an important determinant of reduced serum paraoxonase activity in premenopausal women
Hum. Reprod., December 1, 2006; 21(12): 3157 - 3161.
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