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Hum. Reprod. Advance Access published online on September 9, 2005
Human Reproduction, doi:10.1093/humrep/dei304
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Received July 8, 2005
Revised August 12, 2005
Accepted August 18, 2005

Article

No association between HLA-DRB1 alleles and susceptibility to advanced stage endometriosis in a Korean population

Dong Hee Whang 1, Sung Hoon Kim 2*, Young Min Choi 3, Myoung Hee Park 4, Ji Hyun Noh 5, and Yong Bong Kim 5

1 Department of Laboratory Medicine, Inje University College of Medicine, Seoul Paik Hospital, Seoul
2 Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul
3 Department of Obstetrics & Gynecology, The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul
4 Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul
5 Department of Obstetrics and Gynecology, Inje University College of Medicine, Seoul Paik Hospital, Seoul, Korea

* To whom correspondence should be addressed.
Sung Hoon Kim, E-mail: kimsung{at}amc.seoul.kr


  Abstract

BACKGROUND: The aetiological factors of endometriosis still remain poorly understood. While there is growing evidence that genetic and immunological factors play important roles in the pathogenesis of the disease, HLA-DRB1 alleles have been reported to be associated with the risk of endometriosis in Japanese populations. This study was performed to determine whether susceptibility to advanced endometriosis is also associated with HLA-DRB1 alleles in a Korean population, which is the closest ethnic group to Japanese. METHODS: We recruited 100 Korean patients with advanced endometriosis confirmed by surgical and histolological examinations. HLA-DRB1 genotyping was carried out in two steps. Low to intermediate resolution typing was performed by PCR sequence-specific oligonucle-otide hybridization method, followed by high resolution typing utilizing group-specific amplification and PCR-single strand conformation polymorphism method. Distribution of HLA-DRB1 alleles was compared with that of 800 unrelated ethnically matched individuals as well as 108 healthy female subjects. RESULTS: Genotyping revealed that the distribution of HLA-DRB1 alleles in patients with advanced endometriosis was not different from that in the two control groups. CONCLUSIONS: The findings of the present study suggest that susceptibility of advanced endometriosis is not associated with HLA-DRB1 alleles in a Korean population, which is apparently not the case in the Japanese population.

Keywords: endometriosis/HLA-DRB1 alleles/human leukocyte antigen.
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