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Hum. Reprod. Advance Access published online on October 27, 2005
Human Reproduction, doi:10.1093/humrep/dei327
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received June 14, 2005
Revised August 25, 2005
Accepted August 31, 2005

Article

Comparison of serum FSH and Inhibin B levels between adult male dizygotic and monozygotic twins

Alastair Sutcliffe 1*, Helen A. Spoudeas 2, Devaki Nair 3, Pierre Bouloux 4, Tim Oliver 5, Philip Sambrook 6, Wendy Bannister 7, Cornelis B. Lambalk 8, and Tim Spector 9

1 Department of Child Health, , Royal Free and University College Medical School, NW3 2PF, London, UK
2 Consultant Paediatric Endocrinologist, University College and Great Ormond Street Hospitals, London, UK
3 Department of Chemical Pathology, , Royal Free and University College Medical School, NW3 2PF, London, UK
4 Reader in Endocrinology, Royal Free and University College Medical School, NW3 2PF, London, UK
5 St Bartholomew’s and The Royal London Hospital, London, UK
6 Royal North Shore Hospital, University of Sydney, St Leonards, NSW, Australia 2065
7 Department of Primary Care and Population Sciences, Royal Free and University College Medical School, NW3 2PF, London, UK
8 Division of Reproductive Medicine, Vrije Universiteit Medical Centre (VUMC), Amsterdam, The Netherlands
9 Twin Research and Genetic Epidemiology Unit, St Thomas’s Hospital, London, UK

* To whom correspondence should be addressed.
Alastair Sutcliffe, E-mail: a.sutcliffe{at}medsch.ucl.ac.uk


  Abstract

Background FSH hypersecretion occurs in mothers of dizygotic (DZ) twins. Twinning is inherited via both sexes and transmitted through the female. FSH hypersecretion may thus occur in male DZ twins. METHODS: We assayed FSH and its counter-regulatory hormone, Inhibin B, in 108 adult male DZ and 100 monozygotic (MZ) twins (as controls) and compared our results to published norms. RESULTS: Inhibin B was elevated and higher in DZ compared with MZ twins with similar FSH. CONCLUSION: The normal FSH: Inhibin B endocrine feedback axis is different in adult male DZ twins. This contributes to the theory that the answer to human DZ twinning lies in the actions of FSH and Inhibin, and in their mutual interaction.

Keywords: FSH hypersecretion/inhibin B/twins.
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