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Hum. Reprod. Advance Access published online on November 10, 2005
Human Reproduction, doi:10.1093/humrep/dei343
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received February 9, 2005
Revised September 6, 2005
Accepted September 8, 2005

Article

Indomethacin effect on implantation rates in oocyte recipients

R. Bernabeu 1, M. Roca 2, A. Torres 3*, and J. Ten 4

1 Instituto Bernabeu, Alicante, Medical School, Murcia University, Spain; Reproductive Health Chair, Universidad Miguel Hernández (Alicante), Spain
2 Instituto Bernabeu, Cartagena, Medical School, Murcia University, Spain; Reproductive Health Chair, Universidad Miguel Hernández (Alicante), Spain
3 Department of Health and Social Sciences, Medical School, Murcia University, Spain
4 Instituto Bernabeu, Alicante, Medical School, Murcia University, Spain

* To whom correspondence should be addressed.
A. Torres, E-mail: amtorres{at}um.es


  Abstract

BACKGROUND: Implantation failure is the main limiting factor for success of IVF. Even when transfer techniques are carried out extremely carefully, embryo transfer may produce an endometrial and cervical reaction that may result in an inflammatory response and impaired implantation. There are no formal specifications on the use of indomethacin in reproductive cycles and there are no studies published in the scientific literature on its effect on embryo implantation. Oocyte donation is the best model to evaluate the determinants of implantation. The aim of this study is to evaluate the potential benefit of indomethacin administered at embryo transfer. METHODS: A randomized pilot trial of 136 oocyte recipients was carried out. Seventy-two women received standard specifications plus 100mg of indomethacin rectally given as three doses every 12h starting on the night prior to transfer. RESULTS: Positive HCG (>= 6mUI/ml) occurred in 59.7% of treated women and in 59.4% of women in the control group. Implantation rates were 27.8% in the indomethacin group and 26.4% in the controls. CONCLUSIONS: The indo-menthacin group did not show significantly higher implantation rates. A larger study exploring alternative treatment protocols might be appropriate.

Keywords: embryo transfer/endometrial receptivity/implantation/randomized pilot study.
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