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Hum. Reprod. Advance Access published online on October 27, 2005
Human Reproduction, doi:10.1093/humrep/dei349
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received July 4, 2005
Revised August 28, 2005
Accepted September 20, 2005

Article

Rejection patterns in allogeneic uterus transplantation in the mouse

R. Racho El-Akouri 1*, J. Mölne 2, K. Groth 1, G. Kurlberg 3, and M. Brännström 1

1 Department of Obstetrics and Gynaecology, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
2 Department of Pathology, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
3 Department of Surgery, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden

* To whom correspondence should be addressed.
R. Racho El-Akouri, E-mail: randa.racho{at}obgyn.gu.se


  Abstract

BACKGROUND: Transplantation of the uterus in the mouse has been developed as a model system for research towards human uterine transplantation. Previous studies in a mouse model have demonstrated that a syngeneic uterus transplant can give rise to normal offspring. The aim of this study was to characterize the time course of rejection in a fully allogeneic mouse uterus transplantation model. METHODS: Uteri of BALB/c mice were transplanted to a heterotopic position in C57BL/6 recipients, whose native uteri were left in situ. The blood flow of the uteri, their gross appearance and general histology and the density of T-lymphocytes were examined on postoperative days 2-28. RESULTS: Macroscopic signs of rejection were apparent from day 5. At the light microscopy level, minimal inflammatory changes were seen from day 5 and massive inflammation was seen from day 10 to day 15. At day 28, necrosis and fibrosis were seen. The density of T-lymphocytes (CD3+) was increased in the grafted uterus from day 2 in the myometrium and from day 5 in the endometrium. Blood flow in the grafted uteri was reduced from day 15. CONCLUSION: A murine model to study rejection of allogeneic uterus transplants was characterized. Signs of rejection were seen from day 2 to day 5 and severe rejection was seen from day 10 to day 15. The data will be useful in future studies on immunosuppressants in this model.

Keywords: allogeneic/mouse/rejection/transplantation/uterus.
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