Skip Navigation



Hum. Reprod. Advance Access published online on October 27, 2005
Human Reproduction, doi:10.1093/humrep/dei369
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
21/3/728    most recent
dei369v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Buckingham, K.L.
Right arrow Articles by Chamley, L.W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buckingham, K.L.
Right arrow Articles by Chamley, L.W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received August 16, 2005
Revised September 17, 2005
Accepted September 26, 2005

Article

Antiphospholipid antibodies in serum and follicular fluid--is there a correlation with IVF implantation failure?

K.L. Buckingham 1*, P.R. Stone 2, J.F. Smith 3, and L.W. Chamley 1

1 Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland 1001, New Zealand; Fertility Plus, Greenlane Clinical Centre, Private Bag 92189, Auckland 1003, New Zealand
2 Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland 1001, New Zealand
3 Reproductive Technologies Group, AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton 2001, New Zealand

* To whom correspondence should be addressed.
K.L. Buckingham, E-mail: karen{at}onlinecom.co.nz


  Abstract

BACKGROUND: Antiphospholipid antibodies (aPLs) are associated with infertility, but the mechanism underlying this statistical association is currently obscure. We aimed to investigate the finding that aPLs are concentrated in follicular fluid and to establish if this is associated with a poorer outcome from IVF. METHODS AND RESULTS: In 19.2% of 99 women undergoing IVF, at least one aPL was detected in their serum and/or follicular fluids, but the antibody levels in follicular fluid were not higher than in serum. Women with aPLs had a lower implantation rate (14%) than women without these antibodies (24.1%), but this difference was not significant (P = 0.127). There was also a non-significant reduction in the live birth rate for women with aPLs. In a parallel investigation, 10 sheep immunized with {beta}2 glycoprotein I ({beta}2GPI) or irrelevant control antigens showed strong immune responses, but there were no significant differences between the levels of antibodies in the follicular fluid or serum from {beta}2GPI or control immunized sheep. CONCLUSION: aPLs do not appear to be selectively concentrated in follicular fluids and, when present, do not adversely affect the reproductive outcome of women undergoing IVF.

Keywords: anticardiolipin/antiphosphatidylserine/antiphospholipid antibodies/{beta}2 glycoprotein I/IVF.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
S. M. Nelson and I. A. Greer
The potential role of heparin in assisted conception
Hum. Reprod. Update, November 1, 2008; 14(6): 623 - 645.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. Buckingham and L. Chamley
Reply: Antiphospholipid antibodies in serum and follicular fluid: is there a correlation with IVF implantation failure?
Hum. Reprod., November 1, 2007; 22(11): 3044 - 3045.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
H. Matsubayashi, T. Sugi, T. Arai, M. Shida, A. Kondo, T. Suzuki, S.-i. Izumi, and J. A. McIntyre
Antiphospholipid antibodies in serum and follicular fluid: is there a correlation with IVF implantation failure?
Hum. Reprod., November 1, 2007; 22(11): 3043 - 3044.
[Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
M. Gayed and C. Gordon
Pregnancy and rheumatic diseases
Rheumatology, November 1, 2007; 46(11): 1634 - 1640.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.