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Hum. Reprod. Advance Access published online on November 25, 2005
Human Reproduction, doi:10.1093/humrep/dei403
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received May 16, 2005
Revised October 26, 2005
Accepted October 31, 2005

Article

Value of the sperm chromatin dispersion test in predicting pregnancy outcome in intrauterine insemination: a blind prospective study*

Lourdes Muriel 1, Marcos Meseguer 2, Jose Luis Fernández 1, Juan Alvarez 3, José Remohí 1, Antonio Pellicer 1, and Nicolás Garrido 2 *

1 Sección de Genetica y Unidad de Investigación, Hospital ‘Teresa Herrera’, Complejo Hospitalario Juan Canalejo, A Coruña
2 Instituto Universitario IVI, Valencia, Spain; FIVI, (Fundación IVI) Valencia, Spain
3 Centro de Infertilidad Masculina ANDROGEN, La Coruña and Harvard Medical School, Boston, USA

* To whom correspondence should be addressed.
Nicolás Garrido, E-mail: nicolas.garrido{at}ivi.es


  Abstract

BACKGROUND: Sperm DNA integrity has been used as a new marker of sperm quality in the prediction of pregnancy. Nevertheless, no previous study has been performed by analysing the same samples that were employed in assisted reproduction. The main objective of this work was to correlate sperm chromatin dispersion (SCD), measured by the SCD test, with semen parameters and pregnancy outcome in intrauterine insemination (IUI). METHODS: A total of 100 semen samples obtained from males of couples undergoing IUI were analysed by the SCD test before and after swim-up, and the results were correlated with semen parameters and pregnancy outcome. RESULTS: SCD was negatively correlated with sperm motility in both ejaculated and processed semen. Sperm recovered by swim-up did not show a significant improvement in DNA integrity. No correlation was found between SCD and pregnancy outcome in IUI. CONCLUSIONS: DNA dispersion, as measured by the SCD test, is not correlated with pregnancy outcome in IUI.

Keywords: DNA/intrauterine insemination/sperm/sperm chromatin dispersion test.

*This work was presented at the 21st Annual Meeting of the ESHRE in Copenhagen (Denmark).


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