Hum. Reprod. Advance Access published online on December 16, 2005
Human Reproduction, doi:10.1093/humrep/dei420
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1 University Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, University College London
* To whom correspondence should be addressed. BACKGROUND: Women with polycystic ovary syndrome (PCOS) are assumed to be at increased risk of endometrial cancer (EC), albeit of a more differentiated type with better prognosis than in normal women. This study was designed to test these assumptions, as evidence for them is lacking. METHODS: The prevalence of polycystic ovaries (PCO), as a marker of PCOS, was investigated in ovarian sections from 128 women with EC and 83 with benign gynaecological conditions. The expression of the prognostic markers p53, Ki67, Bcl2 and cyclin D1 was also investigated by immunohisto-chemistry in endometrial tumours from 11 women with PCO and 16 with normal ovaries. RESULTS: Overall, PCO were similarly prevalent in women with EC (8.6%) and benign controls (8.4%); however, in women aged <50 years, PCO were more prevalent in women with EC (62.5 versus 27.3%, P = 0.033). Cyclin D1-expressing endometrial tumours tended to be more prevalent in women with PCO compared to normal ovaries (36.4 versus 6.25%, respectively, P = 0.071). Bcl2-, p53- and Ki67-expressing tumours were similarly prevalent. CONCLUSIONS: The association between PCOS and EC appears confined to premenopausal women. The tendency for cyclin D1-expressing endometrial tumours to be more prevalent in women with PCO challenges the assumption that EC prognosis is improved in women with PCOS.
Received June 2, 2005
Revised October 31, 2005
Accepted November 9, 2005
Article
The association between polycystic ovaries and endometrial cancer
O.C. Pillay 1,
L.F. Wong Te Fong 1,
J.C. Crow 2,
E. Benjamin 3,
T. Mould 4,
W. Atiomo 5,
P.A. Menon 6,
A.J. Leonard 1,
and
P. Hardiman 1 *
2 Department of Histopathology, Royal Free and University College Medical School, University College London
3 Department of Histopathology, University College London Hospitals, London
4 Department of Gynaecological Oncology, University College London Hospitals, London
5 Department of Obstetrics and Gynaecology, Queen’s Medical Centre NHS Trust, Nottingham
6 Department of Histopathology, St Thomas Hospital, London, UK
P. Hardiman, E-mail: p.hardiman{at}medsch.ucl.ac.uk
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