Skip Navigation



Hum. Reprod. Advance Access published online on December 22, 2005
Human Reproduction, doi:10.1093/humrep/dei431
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
21/4/930    most recent
dei431v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Topcu, S.
Right arrow Articles by Muderrisoglu, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Topcu, S.
Right arrow Articles by Muderrisoglu, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received August 22, 2005
Revised October 5, 2005
Accepted October 13, 2005

Article

Do young women with polycystic ovary syndrome show early evidence of preclinical coronary artery disease?

Semra Topcu 1 *, Mustafa Caliskan 1, Emel Ebru Ozcimen 2, Derya Tok 1, Ayla Uckuyu 2, Dogan Erdogan 1, Hakan Gullu 1, Aylin Yildirir 3, Hulusi Zeyneloglu 2, and Haldun Muderrisoglu 3

1 Cardiology Department, Konya Teaching and Medical Research Center, Baskent University, Konya
2 Obstetrics & Gynecology Department, Konya Teaching and Medical Research Center, Baskent University, Konya
3 Cardiology Department, Baskent University Faculty of Medicine, Ankara, Turkey

* To whom correspondence should be addressed.
Semra Topcu, E-mail: semratopcu2003{at}yahoo.com


  Abstract

BACKGROUND: It is thought that women with polycystic ovary syndrome (PCOS) are at increased risk of developing cardiovascular diseases. METHODS: In this study, we used transthoracic echocardiography to measure coronary flow reserve (CFR) in 28 women with PCOS and in 26 healthy women. RESULTS: The PCOS and the control groups were similar in terms of age (27.1 ± 4.5 versus 28.8 ± 4.4 years) and BMI (26.6 ± 5.7 versus 24.7 ± 4.4 kg/m2). Fasting insulin levels and homeostasis model assessment insulin resistance index were higher in the PCOS group. LH, the LH/FSH ratio, total testosterone, free testosterone and androstenedione were higher in the PCOS group. FSH, estradiol, prol-actin, progesterone, cholesterol, triglyceride and high-sensitive C-reactive protein were similar between the two groups, but homocysteine levels were higher in the PCOS group. Baseline diastolic peak flow velocity (DPFV) (25.0 ± 4.6 versus 23.3 ± 2.7 cm/s, P > 0.05), hyperaemic DPFV (71.2 ± 12.8 versus 73.0 ± 12.9 cm/s, P > 0.05) and CFR (2.8 ± 0.8 versus 3.2 ± 0.8 cm/s, P > 0.05) of the left anterior descending coronary artery were similar between the two groups. CONCLUSION: We conclude that in young women with PCOS and without cardiovascular risk factors, CFR is preserved.

Keywords: coronary artery disease/coronary flow reserve/polycystic ovary syndrome.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.