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Hum. Reprod. Advance Access published online on January 12, 2006

Human Reproduction, doi:10.1093/humrep/dei438
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received July 10, 2005
Revised November 6, 2005
Accepted November 14, 2005

Article

Removal of a residual portion of a uterine septum in women of advanced reproductive age: obstetric outcome

Zsolt Kormányos 1 *, Béla G. Molnár 1, and Attila Pál 1

1 Department of Obstetrics and Gynaecology, Faculty of General Medicine, Albert Szent-Györgyi Medical and Pharmacological Centre, University of Szeged, Szeged, Hungary

* To whom correspondence should be addressed.
Zsolt Kormányos, E-mail: kormanyos{at}obgyn.szote.u-szeged.hu


   Abstract

BACKGROUND: To learn more about the obstetric outcome after initial septum resection and remnant septum (≤1 cm) resection. METHODS: In 94 patients with septate uteri who underwent uterine septum resection, the reproductive efficiency was analysed in a prospective observational study. The reproductive outcome was analysed after initial resection and (if required) consecutive procedures. RESULTS: A total of 94 women were enrolled in the study; all had had two or more miscarriages. The septum was completely removed during the first hysteroscopy in 58 (62%) cases. A residual septum was observed in 36 (38%) patients. Subsequent operative hysteroscopy was performed in the cases (29/36; 80.5%) involving repeated miscarriage and unsuccessful conception. The minimum observation time was 24 months. The difference in delivery rate after the first hysteroscopy between those with a normalized uterine cavity (26/58; 44.8%) and those with remnants (7/36; 19.4%) was statistically significant (P < 0.05). In fact, following the normalization of the uterine cavity, 62.1% (18/29) of the patients delivered, as compared with 19.4% of those (7/36) with a residue and Kaplan-Meyer curves revealed a statistically significant difference (P < 0.05). CONCLUSIONS: Women with a remnant uterine septum have an increased chance of successful pregnancy with an improved obstetric outcome after normalization of the uterine cavity.

Keywords: hysteroscopy/infertility/metroplasty/miscarriage/remnant septum.
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