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Hum. Reprod. Advance Access published online on January 12, 2006
Human Reproduction, doi:10.1093/humrep/dei484
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received April 22, 2005
Revised December 2, 2005
Accepted December 9, 2005

Article

Evidence of a high proportion of premature unbalanced separation of sister chromatids in the first polar bodies of women of advanced age

F. Vialard 1 *, C. Petit 2, M. Bergere 1, D.Molina Gomes 3, V. Martel-Petit 4, R. Lombroso 3, Y. Ville 3, H. Gerard 5, and J. Selva 1

1 Department of reproductive biology, cytogenetics, gynaecology and obstetrics, CHI Poissy-Saint Germain, Poissy; Institut National de la Santé et de la Recherche Médicale (INSERM U 407), Faculté de Médecine Lyon-Sud, Oullins
2 Department of reproductive biology and development, CHU de Nancy, Maternité A Pinard, Nancy; Department of genetics & reproductive biology, Laboraroire Lefaure & Petit, Epinal
3 Department of reproductive biology, cytogenetics, gynaecology and obstetrics, CHI Poissy-Saint Germain, Poissy
4 Department of genetics & reproductive biology, Laboraroire Lefaure & Petit, Epinal
5 Department of reproductive biology and development, CHU de Nancy, Maternité A Pinard, Nancy; EA 3442 "Génétique, Signalisation, Différenciation" Université Henri Poincaré, Nancy, France

* To whom correspondence should be addressed.
F. Vialard, E-mail: fvialard{at}hotmail.com


  Abstract

BACKGROUND: Maternal ageing is the only aetiological factor unequivocally linked to aneuploidy. Two mechanisms seem to explain these abnormalities in oocytes: non-disjunction and premature unbalanced separation of sister chromatids (PSSC). Previous studies of unfertilized oocytes argue for a major role of PSSC in the aetiology of aneuploidy for women of advanced age, but in vitro ageing of the oocytes could influence the results. METHODS: Owing to the high prevalence of aneuploidy in women of advanced age, chromosomal screening of the first polar body just before ICSI was offered to women (from 38 years of age) included in an assisted reproduction programme. RESULTS: Among 141 oocytes from 29 women (mean age 40 years and 2 months), 43 (30.5%) were abnormal. Sixty-five abnormalities were found and PSSC was involved in 80% of cases. CONCLUSION: These results are in accordance with previous studies and confirm, in ‘fresh’ oocytes, the major role of PSSC in the aetiology of aneuploidy in women of advanced age.

Keywords: aneuploidy/age/premature separation of sister chromatids/cohesin/polar body.
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