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Hum. Reprod. Advance Access published online on January 12, 2006
Human Reproduction, doi:10.1093/humrep/dei489
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received June 16, 2005
Revised October 18, 2005
Accepted December 13, 2005

Article

Stellate transformation of invasive trophoblast: a distinct phenotype of trophoblast that is involved in decidual vascular remodelling and controlled invasion during pregnancy

J.C. Shih 1, C.L. Chien 2 *, H.N. Ho 3, W.C. Lee 2, and F.J. Hsieh 4

1 Department of Obstetrics & Gynecology, National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan
2 Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan
3 Department of Obstetrics & Gynecology, National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Immunology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
4 Department of Obstetrics & Gynecology, National Taiwan University College of Medicine, Taipei, Taiwan

* To whom correspondence should be addressed.
C.L. Chien, E-mail: clc{at}ha.mc.ntu.edu.tw


  Abstract

BACKGROUND: Successful implantation relies on the tightly regulated invasion of extravillous trophoblasts (EVTs). However, little is known about their phenotypic differentiation and relevant motile behaviour. Furthermore, the cell-cell interactions between EVTs and decidual arterioles during physiological transformation are also poorly understood. METHODS: A total of 128 decidual specimens from early and late gestations containing components of EVTs and spiral arterioles were investigated using immunohistochemistry and periodic acid-Schiff reaction. RESULTS: Unipolar, tadpole-like EVTs are observed throughout the interstitial area, with a tendency to decrease along the invasive pathway. The stellate differentiation of the EVTs is identified around and inside decidual arterioles or in the third-trimester myometrium. Furthermore, stellate transformation of EVTs precedes its interactions with the decidual arteriole. These specialized stellate trophoblasts invade and infiltrate the tunica media, accompanying lacuna formation inside the vessel wall and perturbation of actin fibre alignment of the tunica media. CONCLUSION: Stellate transformation of trophoblasts may explain controlled invasion of EVTs and probably plays a key role in initiating cell-cell interaction in decidual vascular remodelling.

Keywords: interstitial trophoblast/pregnancy/stellate transformation/vascular remodelling.
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