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Hum. Reprod. Advance Access published online on January 26, 2006
Human Reproduction, doi:10.1093/humrep/dei493
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received September 23, 2005
Revised December 7, 2005
Accepted December 14, 2005

Article

Ovarian response to stimulation of HIV-positive patients during IVF treatment: a matched, controlled study

Valérie Martinet 1, Yannick Manigart 1, Serge Rozenberg 1, Benedicte Becker 1, Michèle Gerard 2, and Annick Delvigne 1 *

1 Department of Obstetrics and Gynaecology, Université Libre de Buxelles, Brussels, Belgium
2 Department of Internal Medicine, Division of Infectious Diseases, CHU Saint-Pierre, Université Libre de Buxelles, Brussels, Belgium

* To whom correspondence should be addressed.
Annick Delvigne, E-mail: annick_delvigne{at}stpierre-bru.be


  Abstract

BACKGROUND: Our aim was to compare the ovarian response of HIV-positive and -negative patients during IVF. METHODS: Setting - HIV and IVF reference university hospital. Twenty-seven HIV-infected patients who had undergone IVF between March 2000 and March 2005 were matched with 77 HIV-negative patients for age, aetiology of infertility, whether it was primary or secondary infertility, duration of infertility, history of pelvic surgery and type of pituitary inhibition. Outcome - poor responders were defined using one of the following criteria: a cancelled cycle (for insufficient ovarian response), less than four mature follicles (≥16 mm), peak serum levels of E2 lower than 1000 pg/ml. RESULTS: There were no differences between the two groups of patients for the matched criteria. The proportion of African women and of women with a history of pelvic inflammatory disease was significantly higher among HIV patients than among the control group. With the exception of a lower number of transferred embryos among HIV-positive patients versus HIV-negative ones (1.3 versus 1.9; P = 0.035), there was no significant difference between the two groups of patients regarding ovarian response parameters. CONCLUSION: HIV-infected patients who are in good general condition and who are matched to a control group present a similar ovarian response to stimulation, suggesting the existence of a similar ovarian reserve.

Keywords: case-control study/HIV/IVF/poor response.
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