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Hum. Reprod. Advance Access published online on January 31, 2006
Human Reproduction, doi:10.1093/humrep/dei503
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received October 6, 2005
Revised December 16, 2005
Accepted December 23, 2005

Article

Obstetric and perinatal outcome and preliminary results of development of children born after in vitro maturation of oocytes

Viveca Söderström-Anttila 1 *, Teija Salokorpi 2, Miia Pihlaja 1, Silve Serenius-Sirve 3, and Anne-Maria Suikkari 1

1 The Family Federation of Finland, Infertility Clinic, Helsinki, Finland
2 The Mannerheim League for Child Welfare, The Foundation for Rehabilitation of Children and Young People, Helsinki, Finland
3 Barnavårdsföreningen i Finland r.f./ADHD-centre, Stenbäckinkatu, Helsinki, Finland

* To whom correspondence should be addressed.
Viveca Söderström-Anttila, E-mail: viveca.soderstrom-anttila{at}vaestoliitto.fi


  Abstract

BACKGROUND: Careful follow-up of children born after in vitro maturation (IVM) of human oocytes is essential because the technique is still very new. METHODS: Obstetric and perinatal data were collected from all deliveries after IVM treatment during 1999-2004. The growth and development of IVM children was assessed at 6, 12 and 24 months using Muenchener Funktionelle Entwicklungs Diagnostik and Bayley Scales of Infants. RESULTS: In total, 43 women [age 31.2 ± 3.9 (mean ± SD) years] gave birth to 40 singleton infants and three sets of twins (multiple rate 7.0%). Obstetric complications occurred in 15 pregnancies (35%). The mean birthweight of singleton infants was 3550 ± 441 g and that of twins 2622 ± 194 g. The rate of preterm birth infants was 5% in singletons. No perinatal deaths occurred. At the age of 12 months, eight children (19%) expressed minor developmental problems and one girl was found to have optical glioma. At 2 years of age, neuropsychological development was within the normal range. CONCLUSIONS: The obstetric and perinatal outcome was good, and the mean birthweight of the infants was normal. Minor developmental delay was overexpressed at 12 months, but the development of the children was normal at 2 years.

Keywords: birthweight/follow-up of children/IVM/obstetric/perinatal.
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